5-脂氧合酶和环氧合酶-2在致癌作用共同调节作用及其由吸烟在结肠推广的发生

Title:The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons

Volume: 23 Issue: 11

Author(s): J. Shen, W.X. Li, Z.G. Xiao, L. Zhang, M.X. Li, L.F. Li, W. Hu, L. Lu, F. Boudreau, C.H. Cho

Affiliation:

关键词: 5 -脂氧合酶，环氧合酶 - 2，香烟烟雾，结肠癌，lincofelone，透明质酸。

摘要: The arachidonic acid metabolizing enzymes, cyclooxygenase-2 (COX-2) and 5- lipoxygenase (5-LOX), are both highly expressed during the carcinogenesis in colons. Cigarette smoking promotes these carcinogenic processes at the early stage during adenoma formation. In this article, the involvement of COX-2 and 5-LOX, alongside with the dual COX/5-LOX inhibitors in colorectal cancer development is introduced. The co-regulation of 5-LOX and COX-2 in colon cancer growth and its relationship with cigarette smoke and hyaluronic acid-CD44v6 is also described. It is envisaged that dual inhibition of 5-LOX/COX could be the most promising therapeutic option for the treatment of colorectal cancer in humans.

Cite this article as:

J. Shen, W.X. Li, Z.G. Xiao, L. Zhang, M.X. Li, L.F. Li, W. Hu, L. Lu, F. Boudreau, C.H. Cho , The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons, Current Medicinal Chemistry 2016; 23 (11) . https://dx.doi.org/10.2174/0929867323666160321122431