Preliminary Pharmacological Screening of Some Thiosemicarbazide, s-triazole, and Thiadiazole Derivatives

Title:Preliminary Pharmacological Screening of Some Thiosemicarbazide, s-triazole, and Thiadiazole Derivatives

Volume: 15 Issue: 6

Author(s): Agata Paneth, Monika Wujec, Tomasz Plech, Edyta Kuśmierz, Dominika Hagel, Szymon Kosiek, Ewa Jagiello-Wójtowicz, Iwona Piątkowska-Chmiel, Mariola Herbet, Magdalena Izdebska, Ewa Kędzierska and Jolanta Orzelska-Górka

Affiliation:

Keywords: Analgesic activity, pharmacological screening, thiadiazoles, thiosemicarbazides, triazoles.

Abstract: Two thiosemicarbazide derivatives 1 and 2, three 2-amino-1,3,4-thiadiazole derivatives 3-5, and three N1- substituted-4-methyl-1,2,4-triazole-5-thione derivatives 6-8 were synthesized and evaluated for their central nervous system effects using rodent behavioral models. With the exception of 6, all compounds were devoid of neurotoxicity and they did not affect the body temperature of mice. New lead structures 1-4 with potential analgesic activity were identified.

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Paneth Agata, Wujec Monika, Plech Tomasz, Kuśmierz Edyta, Hagel Dominika, Kosiek Szymon, Jagiello-Wójtowicz Ewa, Piątkowska-Chmiel Iwona, Herbet Mariola, Izdebska Magdalena, Kędzierska Ewa and Orzelska-Górka Jolanta, Preliminary Pharmacological Screening of Some Thiosemicarbazide, s-triazole, and Thiadiazole Derivatives, CNS & Neurological Disorders - Drug Targets 2016; 15 (6) . https://dx.doi.org/10.2174/1871527315666160321110818