摘要
骨性关节炎是一种致残疾疼痛,预计在未来几十年将增加,并且疾病调节抗关节炎药物(DMOADs)将非常理想地辅助缓解症状和结构重建,因为他们可以减缓疾病的进程。硫酸软骨和氨基葡萄糖已观察到参与骨关节炎动物模型和细胞代谢的各种有益效果的临床试验。临床试验报告这些生物制剂单独或组合的有益效果,对疼痛和功能,以及结构修饰能力分析报告和最近的荟萃分析。然而,这些作为疾病调节抗关节炎药物的生物活性(宏观)分子的有效性与报道的随机对照试验场不匹配。目前的研究有不同的证据表明硫酸软骨素和氨基葡萄糖可以调节疾病的进展,但同时也没有绝对的把握修改病程疗效。这篇综合性的综述旨在阐明这些化合物对骨关节炎患者分子/药物治疗的有益作用。
关键词: 硫酸软骨素,氨基葡萄糖,骨性关节炎,疾病调节抗关节炎药物,软骨。
Current Medicinal Chemistry
Title:Chondroitin Sulfate and Glucosamine as Disease Modifying Anti- Osteoarthritis Dru gs (DMOADs)
Volume: 23 Issue: 11
Author(s): Veronica Mantovani, Francesca Maccari, Nicola Volpi
Affiliation:
关键词: 硫酸软骨素,氨基葡萄糖,骨性关节炎,疾病调节抗关节炎药物,软骨。
摘要: Osteoarthritis is a disabling affliction expected to increase in the coming decades, and disease- modifying osteoarthritis drugs (DMOADs) would be highly desirable adjuncts to symptomatic relief and structure reconstruction as they may delay the disease process. Chondroitin sulfate and glucosamine have been observed to exert beneficial effects on the metabolism of various cells involved in osteoarthritis as well as in animal models and clinical trials. Clinical trials have reported beneficial effects of both these biological agents, alone or in combination, on pain and functions as well as their structure-modifying capacity reported and analyzed in recent meta-analyses. Nonetheless, the effectiveness of these bioactive (macro)molecules as DMOADs reported from randomized trials is mismatched. Current studies with varying levels of evidence suggest that chondroitin sulfate and glucosamine can modify the disease progression but at the same time there are not absolute certainties on their efficacy in modifying the course of the disease. This comprehensive review aims to clarify the role of these compounds in the therapeutic molecules/ drugs useful to patients affected by osteoarthritis.
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Cite this article as:
Veronica Mantovani, Francesca Maccari, Nicola Volpi , Chondroitin Sulfate and Glucosamine as Disease Modifying Anti- Osteoarthritis Dru gs (DMOADs), Current Medicinal Chemistry 2016; 23 (11) . https://dx.doi.org/10.2174/0929867323666160316123749
DOI https://dx.doi.org/10.2174/0929867323666160316123749 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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