Abstract
The genocentric view of disease that has dominated biomedical science for the past 25 years has proven insufficient for determining causation of most diseases. The technology arising from genomic efforts, however, provides powerful tools for developing the more meaningful cellular and molecular understanding of disease causation, particularly as it is affected by environmental and behavioral parameters. The Environmental Genome Project, the Mouse Genetic Variation Mapping Initiative, and the Comparative Toxicogenomics Initiative are discussed as projects that aim to capitalize on genomic technology in ways that better define the environmental and genetic underpinnings of chronic diseases and disorders.
Keywords: toxicogenomics, environmental genome project, gene-environment interactions, comparative toxicogenomics database
Current Genomics
Title: Use of ‘Omic’ Approaches in Unraveling Mechanisms of Gene-Environment Interactions
Volume: 5 Issue: 1
Author(s): Kenneth Olden
Affiliation:
Keywords: toxicogenomics, environmental genome project, gene-environment interactions, comparative toxicogenomics database
Abstract: The genocentric view of disease that has dominated biomedical science for the past 25 years has proven insufficient for determining causation of most diseases. The technology arising from genomic efforts, however, provides powerful tools for developing the more meaningful cellular and molecular understanding of disease causation, particularly as it is affected by environmental and behavioral parameters. The Environmental Genome Project, the Mouse Genetic Variation Mapping Initiative, and the Comparative Toxicogenomics Initiative are discussed as projects that aim to capitalize on genomic technology in ways that better define the environmental and genetic underpinnings of chronic diseases and disorders.
Export Options
About this article
Cite this article as:
Olden Kenneth, Use of ‘Omic’ Approaches in Unraveling Mechanisms of Gene-Environment Interactions, Current Genomics 2004; 5 (1) . https://dx.doi.org/10.2174/1389202043489980
DOI https://dx.doi.org/10.2174/1389202043489980 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Bisphosphonate Anticancer Activity in Multiple Myeloma
Anti-Cancer Agents in Medicinal Chemistry Cancer Invasion and Metastasis: Discovering New Targets For Diagnosis and Therapeutics
Current Signal Transduction Therapy Can Targeted Therapy be Successful without Metronomic Scheduling ?
Current Topics in Medicinal Chemistry Meet Our Editorial Board Member:
Current Psychiatry Reviews The Role of Osteopontin in Experimental Autoimmune Encephalomyelitis (EAE) and Multiple Sclerosis (MS)
Inflammation & Allergy - Drug Targets (Discontinued) Gold - Old Drug with New Potentials
Current Medicinal Chemistry Cationic Lipophilic Radiotracers for Functional Imaging of Multidrug Resistance
Current Radiopharmaceuticals Drug Targeting to the Brain - A Review
Current Nanoscience Drug-Induced Thromboembolic Events in Patients with Malignancy
Cardiovascular & Hematological Disorders-Drug Targets Mechanisms of ERK1/2 Regulation by Seven-Transmembrane-Domain Receptors
Current Pharmaceutical Design Mechanisms of Drug Resistance to Vascular Endothelial Growth Factor (VEGF) Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Radiotracers in Oncology
Current Radiopharmaceuticals Role of Natural Phenolic Compounds in Cancer Chemoprevention via Regulation of the Cell Cycle
Current Pharmaceutical Biotechnology An Approach to Treatment of Liver Cancer by Novel Glycyrrhizin Derivative
Anti-Cancer Agents in Medicinal Chemistry Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids
Current Topics in Medicinal Chemistry The Cannabinoid 2 Receptor as a Potential Therapeutic Target for Sepsis
Endocrine, Metabolic & Immune Disorders - Drug Targets CDKN2B-AS1: An Indispensable Long Non-coding RNA in Multiple Diseases
Current Pharmaceutical Design Proceedings of the 1<sup>st</sup> Puerto Rico Biobanking Workshop
Reviews on Recent Clinical Trials Legumes: A Healthy and Ecological Source of Flavonoids
Current Nutrition & Food Science Based on Nucleotides Analysis of Tumor Cell Lines to Construct and Validate a Prediction Model of Mechanisms of Chemotherapeutics
Anti-Cancer Agents in Medicinal Chemistry