摘要
阿尔茨海默氏病(AD)是目前在人类最研究的神经退行性疾病之一。首次在1907报告,该疾病有一个占约5%的情况下家族性的形式,而其余的,散发性的情况下是多因素的病因。后一种形式的疾病进展有特定的病理和功能特征,病因不明。一些作者提出了阿尔茨海默氏病的病毒病因,而其他牵连许多性传染病。本文比较研究以及参与了阿尔茨海默氏病的发展影响神经性病毒的途径和效果的途径。结果惊人的相似,并且提供了基于阿尔茨海默氏病的病因病原体有说服力的作用途径。
关键词: 阿尔茨海默病,β-淀粉样蛋白,细胞周期再入,单纯疱疹病毒,单纯疱疹病毒,tau蛋白的病理变化
Current Alzheimer Research
Title:Connections Between Herpes Simplex Virus Type 1 and Alzheimer's Disease Pathogenesis
Volume: 13 Issue: 9
Author(s): James McNamara and Teresa Ann Murray
Affiliation:
关键词: 阿尔茨海默病,β-淀粉样蛋白,细胞周期再入,单纯疱疹病毒,单纯疱疹病毒,tau蛋白的病理变化
摘要: Alzheimer’s disease (AD) is currently one of the most studied neurodegenerative disorders in humans. First reported in 1907, the disease has a familial form which represents approximately 5% of cases, while the remaining, sporadic cases are of multifactorial etiology. The disease progression of the latter form has specific pathological and functional characteristics, which have unknown etiology. Several authors have proposed a viral etiology for AD, while others implicate many neurotropic infectious agents. This review compares research findings regarding pathways and effects of neuropathological viruses with the pathways and effects involved in the progression of AD. The similarities are striking and provide a compelling argument for a pathogen-based etiology of AD.
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Cite this article as:
James McNamara and Teresa Ann Murray , Connections Between Herpes Simplex Virus Type 1 and Alzheimer's Disease Pathogenesis, Current Alzheimer Research 2016; 13 (9) . https://dx.doi.org/10.2174/1567205013666160314150136
DOI https://dx.doi.org/10.2174/1567205013666160314150136 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |

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