单纯疱疹病毒1型与阿尔茨海默病发病机制的关系

Title:Connections Between Herpes Simplex Virus Type 1 and Alzheimer's Disease Pathogenesis

Volume: 13 Issue: 9

Author(s): James McNamara and Teresa Ann Murray

Affiliation:

关键词: 阿尔茨海默病，β-淀粉样蛋白，细胞周期再入，单纯疱疹病毒，单纯疱疹病毒，tau蛋白的病理变化

摘要: Alzheimer’s disease (AD) is currently one of the most studied neurodegenerative disorders in humans. First reported in 1907, the disease has a familial form which represents approximately 5% of cases, while the remaining, sporadic cases are of multifactorial etiology. The disease progression of the latter form has specific pathological and functional characteristics, which have unknown etiology. Several authors have proposed a viral etiology for AD, while others implicate many neurotropic infectious agents. This review compares research findings regarding pathways and effects of neuropathological viruses with the pathways and effects involved in the progression of AD. The similarities are striking and provide a compelling argument for a pathogen-based etiology of AD.

Cite this article as:

James McNamara and Teresa Ann Murray , Connections Between Herpes Simplex Virus Type 1 and Alzheimer's Disease Pathogenesis, Current Alzheimer Research 2016; 13 (9) . https://dx.doi.org/10.2174/1567205013666160314150136