摘要
在这项前瞻性纵向研究中,在3年期间进行了大样本的遗忘型轻度认知功能障碍患者,我们的研究最近提出的建议,从轻度认知功能障碍患者到阿尔茨海默病患者在长期记忆测试中基线未矫正得到的分数比校正年龄和教育矫正评分在预测更可靠。实验样本包括270例遗忘型轻度认知功能障碍患者,他们经历了在基线和随访的大量的神经学和神经心理学检查,此进程进行至少3年。在后续的80例患者已转换为明显的老年痴呆症。原数据,校正年龄,教育矫正,充分矫正,RAVLT即时和延迟回忆的预测能力得分由ROC曲线下面积(AUCs)检查相比,所有这些成绩评估(原数据或校正)评分达到更好的可靠性预测转化为痴呆。条件(aMCI的稳定与转换)进行了分析评估比值比的校正和RAVLT即时和延迟回忆得分logistic回归导致裸眼。即使在即时和延迟回忆火箭“原成绩普遍高于其他各个校正分数,这些差异没有达到统计学意义的水平,不支持的说法,未经调整的测试成绩优于年龄和教育矫正评分预测进展从轻度认知功能障碍患者到阿尔茨海默病患者。
关键词: 遗忘型轻度认知功能障碍转化,阿尔茨海默氏病,年龄和教育矫正评分,RAVLT记忆测试,原始分数,裸的即时和延迟回忆。
Current Alzheimer Research
Title:Are Raw Scores on Memory Tests Better than Age- and Education- Adjusted Scores for Predicting Progression from Amnesic Mild Cognitive Impairment to Alzheimer Disease ?
Volume: 13 Issue: 12
Author(s): Davide Quaranta, Guido Gainotti, Maria Gabriella Vita, Giordano Lacidogna, Eugenia Scaricamazza, Chiara Piccininni and Camillo Marra
Affiliation:
关键词: 遗忘型轻度认知功能障碍转化,阿尔茨海默氏病,年龄和教育矫正评分,RAVLT记忆测试,原始分数,裸的即时和延迟回忆。
摘要: In this prospective longitudinal study, conducted in a large sample of amnestic MCI patients over a three-year period, we investigated the recently advanced proposal that unadjusted test scores obtained at baseline on long-term memory tests are more reliable than age- and education-corrected scores in predicting progression from aMCI to AD. Our experimental sample consisted of 270 aMCI patients who underwent extensive neurological and neuropsychological examinations both at baseline and at the follow-up, conducted at least 3 years later. At the follow-up 80 patients had converted to overt dementia. The predictive capacity of raw, age-corrected, education-corrected and fully corrected scores on RAVLT immediate and delayed recall was compared by examining the area under the ROC curves (AUCs) of all of these scores to assess which (raw or corrected) scores achieves the better reliability in predicting conversion to dementia. The condition (aMCI stable vs converted) was analyzed to assess the odds ratios resulting from a logistic regression on the corrected and uncorrected scores of RAVLT immediate and delayed recall. Even if both in immediate and in delayed recall the ROCs of ‘raw scores’ were generally higher than the other ROCs on corrected scores, these differences did not reach the level of statistical significance, failing to support the claim that unadjusted test scores are superior to age- and education-corrected scores in predicting progression from aMCI to AD.
Export Options
About this article
Cite this article as:
Davide Quaranta, Guido Gainotti, Maria Gabriella Vita, Giordano Lacidogna, Eugenia Scaricamazza, Chiara Piccininni and Camillo Marra , Are Raw Scores on Memory Tests Better than Age- and Education- Adjusted Scores for Predicting Progression from Amnesic Mild Cognitive Impairment to Alzheimer Disease ?, Current Alzheimer Research 2016; 13 (12) . https://dx.doi.org/10.2174/1567205013666160314145522
DOI https://dx.doi.org/10.2174/1567205013666160314145522 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Clinical and Therapeutic Challenges when Psychiatric Disorders Occur in Neurological Diseases: A Narrative Review
Current Psychiatry Research and Reviews Astrocyte-Microglia Cooperation in the Expression of a Pro-Inflammatory Phenotype
CNS & Neurological Disorders - Drug Targets The Emerging Role of Metabotropic Glutamate Receptors in the Pathophysiology of Chronic Stress-Related Disorders
Current Neuropharmacology Types of Voltage-Gated Calcium Channels: Molecular and Electrophysiological Views
Current Hypertension Reviews New Generation of Orally Disintegrating Tablets for Sustained Drug Release: A Propitious Outlook
Current Drug Delivery Phytochemicals as Prototypes for Pharmaceutical Leads Towards Drug Development Against Diabetic Cardiomyopathy
Current Pharmaceutical Design Role of COL4A1 in Basement-Membrane Integrity and Cerebral Small-Vessel Disease. The COL4A1 Stroke Syndrome
Current Medicinal Chemistry Cycle Helmets for Children- Education or Enforcement?
Current Pediatric Reviews Fructose 1,6-Bisphosphate: A Summary of Its Cytoprotective Mechanism
Current Medicinal Chemistry Unexpected Effects of Acetylcholine Precursors on Pilocarpine Seizure- Induced Neuronal Death
Current Neuropharmacology The Effects of Hydroalcoholic Extract of Pinus eldarica on Hippocampal Tissue Oxidative Damage in Pentylenetetrazole-Induced Seizures in Rat
Current Nutrition & Food Science Preface:
Recent Patents and Topics on Imaging (Discontinued) Recent Updates of N-Type Calcium Channel Blockers with Therapeutic Potential for Neuropathic Pain and Stroke
Current Topics in Medicinal Chemistry Drug Repositioning for Treatment of Movement Disorders: From Serendipity to Rational Discovery Strategies
Current Topics in Medicinal Chemistry Synthesis and Evaluation of Novel Diazaspiro Hydantoins as Potential Anticonvulsants
Central Nervous System Agents in Medicinal Chemistry Biodistribution Processes as Underestimated Confounders in Translational Stroke Research
Current Medicinal Chemistry Editorial [Hot Topic: Calcium Regulatory Proteins as Therapeutic Targets (Guest Editor: Livia C. Hool)]
Current Drug Targets Symptomatic Treatment of Chronic Neuropathic Pain with Gabapentin Clinical Practice and Research Prospective
Current Neuropharmacology Cardioembolic Stroke: Clinical Features, Specific Cardiac Disorders and Prognosis
Current Cardiology Reviews Lamotrigine as an Effective Treatment for Behavioral Disorders
Letters in Drug Design & Discovery