摘要
肿瘤基质(TS)在肿瘤发展的各个步骤中起着相关的作用。我们在这里提出了与癌细胞以及它们之间相互作用的几个基本方面。解析这些作用是了解肿瘤免疫逃逸和耐药性的重要方面。此外,更好的理解将引入新的和更有效的治疗方法,被操纵的基质可能会成为阻碍肿瘤的生长。我们的团队和其他团队都依靠多能间充质/干细胞(MSC)来作为抗癌工具使用,因为这些假定的TS细胞的前体可以提供有效的凋亡诱导剂。多模态武装的MSC可以针对多种体外癌症,当注射到体内时,他们将肿瘤介导的细胞死亡作为靶点,对正常组织也没有明显的毒性。然而这些策略的几个方面都需要进一步的调查,它们共同表明,如何利用MSC作为一个工具来影响癌症细胞的命运,创造出新一代的抗癌策略。
关键词: 肿瘤基质;MSC;TRAIL; 胰腺癌;肉瘤。
Current Drug Targets
Title:Tumor Stroma Manipulation By MSC
Volume: 17 Issue: 10
Author(s): Giulia Grisendi, Carlotta Spano, Filippo Rossignoli, Naomi D'souza, Giulia Golinelli, Agnese Fiori, Edwin M Horwitz and Valentina Guarneri, Federico Piacentini, Paolo Paolucci, Massimo Dominici
Affiliation:
关键词: 肿瘤基质;MSC;TRAIL; 胰腺癌;肉瘤。
摘要: Tumor stroma (TS) plays relevant roles in all steps of cancer development. We here address several fundamental aspects related with the interaction between cancer cells and their stromal counterparts. Dissecting these players is of pivotal importance to understand oncogenesis, immunoescape and drug resistance. In addition, this better comprehension will allow the introduction of novel and more effective therapeutic approaches where manipulated stromal elements may become detrimental for tumor growth. Our group and others rely on the use of multipotent mesenchymal stromal/stem cells (MSC) as anti-cancer tools, since these putative TS cell precursors can deliver potent apoptosis-inducing agents. Multimodal-armed MSC can target a variety of cancers in vitro and, when injected in vivo, they localize into tumors mediating cell death without evident toxicities to normal tissues. While several aspects of these strategies shall require further investigations, these approaches collectively indicate how TS manipulation by MSC represents a tool to influence the fate of cancer cells, creating a new generation of anti-cancer strategies.
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Giulia Grisendi, Carlotta Spano, Filippo Rossignoli, Naomi D'souza, Giulia Golinelli, Agnese Fiori, Edwin M Horwitz and Valentina Guarneri, Federico Piacentini, Paolo Paolucci, Massimo Dominici , Tumor Stroma Manipulation By MSC, Current Drug Targets 2016; 17 (10) . https://dx.doi.org/10.2174/1389450117666160307143226
DOI https://dx.doi.org/10.2174/1389450117666160307143226 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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