Abstract
A review focused on different methodologies applied as effective tools for the construction of β phosphapeptides starting from βamino phosphonic and phosphinic acid derivatives as building blocks is reported. βPhosphapeptides can be considered as mimetics of peptides derived from βamino acids, in which the carbon atom of carboxylic acid group is replaced by a phosphorus atom, and these compounds have attracted a particular interest in the preparation of isosteric or bioisosteric analogs of natural products and enzyme inhibitors.
Keywords: phosphapeptides, amino phosphonic, amino acids
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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