异戊二烯化合物在血管生成规律中的作用：机会和挑战

Title:Role of Isoprenoid Compounds on Angiogenic Regulation: Opportunities and Challenges

Volume: 23 Issue: 9

Author(s): Angela R. Guerra, Iola F. Duarte, Maria F. Duarte

Affiliation:

关键词: 血管生成，天然产物，单帖，倍半萜，二萜，三萜，四萜。

摘要: Isoprenoids represent one of the largest classes of phytochemicals. The structural diversity of these compounds, as well as their remarkable biological activities, makes them suitable candidates for the development of novel therapeutic agents. Several isoprenoids have demonstrated promising potential in the modulation of angiogenesis processes, and therefore provide an appealing alternative and/or addition to the available pharmacotherapies. These compounds could be used per se or combined with standard therapies, which can potentially reduce the undesired secondary effects. Compounds like the sesquiterpenoid artemisinin, and its derivatives, or the diterpenoid triptolide have been successfully tested in a broad range of models (in vitro and in vivo). Moreover, sesquiterpenoids seem to be a promising resource of natural angiogenic modulators, as it can be attested by the significant number of recent publications in this subject. On the other hand, other isoprenoids, such as the triterpenoid ursolic acid, are still under-explored and further studies are needed to understand their role within angiogenic process. Further insights into isoprenoids mode of action in angiogenesis will hopefully pave the way towards their successful clinical use.

Cite this article as:

Angela R. Guerra, Iola F. Duarte, Maria F. Duarte , Role of Isoprenoid Compounds on Angiogenic Regulation: Opportunities and Challenges, Current Medicinal Chemistry 2016; 23 (9) . https://dx.doi.org/10.2174/0929867323666160217123822