摘要
背景:虽然外周血脂肪因子与胰岛素水平被认为是阿尔茨海默病(AD)的生物标志物,但是脂肪细胞因子与胰岛素在血液中的水平研究是没有确凿的。我们设计了这项荟萃分析来验证是否外周脂肪细胞因子与胰岛素可作为AD诊断的候选生物标志物。方法:我们进行了复制研究血清,还进行了一项荟萃分析估计AD患者和对照组之间外周血脂肪因子与胰岛素水平的不同。在荟萃分析的部分,合并加权均数差(WMD)和95%可信区间(CI)是用来比较不同组的脂肪细胞因子与胰岛素水平。结果:根据我们的复制研究,瘦素水平有明显降低,但在阿尔茨海默病患者血液中脂联素和胰岛素水平明显高于对照组。我们最终确定了四研究瘦素,四项脂联素的研究和十一项胰岛素的研究。从随机效应模型,混合性瘦素、脂联素、胰岛素对AD患者与对照组相比有-3.90微克/毫升(95%可信区间:[ -5.68,2.13 ]),9.42µ克/毫升(95%可信区间:[ 4.21,14.62 ]),和2.86µIU/mL(95%可信区间:[ 1.21,4.50 ])。结论:我们的复制研究和荟萃分析支持在相关控制下AD患者中瘦素水平较降低和脂联素与胰岛素水平升高,并指出他们的潜在价值作为AD患者重要的危险因素。进一步的研究,使用标准化检测瘦素,脂联素和胰岛素测量,仍然需要在AD患者的外周血瘦素,脂联素和胰岛素水平的潜在变化。
关键词: 阿尔茨海默病、脂肪因子、瘦素、脂联素、胰岛素、血浆、血清。
Current Alzheimer Research
Title:Peripheral Blood Adipokines and Insulin Levels in Patients with Alzheimer's Disease: A Replication Study and Meta-Analysis
Volume: 13 Issue: 3
Author(s): Jing Ma, Wei Zhang, Hui-Fu Wang, Zi-Xuan Wang, Teng Jiang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan
Affiliation:
关键词: 阿尔茨海默病、脂肪因子、瘦素、脂联素、胰岛素、血浆、血清。
摘要: Background: Although peripheral blood adipokines and insulin levels have been considered to be biomarkers of Alzheimer’s disease (AD), previous researches about levels of adipokines and insulin in blood are no conclusive. We designed this meta-analysis to validate whether peripheral adipokines and insulin can be used as a candidate biomarker in AD diagnosis. Methods: We carried out a replication study in serum by ourselves and further conducted a meta-analysis to estimate the different levels of peripheral blood adipokines and insulin between AD patients and controls. In the section of meta-analysis, the pooled weighted mean difference (WMD) and 95% confidence interval (CI) was used to compare the levels of adipokines and insulin in different groups. Results: According to our replication study, there is statistically significant lower in the levels of leptin, but conspicuous higher in the levels of adiponectin and insulin in the blood of AD patients than controls. We finally identified four studies for leptin, four studies for adiponectin and eleven studies for insulin. From the random-effect model, the pooled WMD of the levels of leptin, adiponectin and insulin of AD subjects compared with the controls was -3.90 ng/ml (95% CI: [-5.68, -2.13]), 9.42 µg/mL (95% CI: [4.21, 14.62]), and 2.86 µIU/ml (95% CI: [1.21, 4.50]), respectively. Conclusion: Our replication study and meta-analysis support lower levels of leptin and higher levels of adiponectin and insulin in AD patients with respect to controls, and indicate their potential values as important risk factors for AD. Further researches that using standardized assay for leptin, adiponectin, and insulin measurement are still needed to reveal the potential change of peripheral blood leptin, adiponectin, and insulin levels in AD participants.
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Jing Ma, Wei Zhang, Hui-Fu Wang, Zi-Xuan Wang, Teng Jiang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan , Peripheral Blood Adipokines and Insulin Levels in Patients with Alzheimer's Disease: A Replication Study and Meta-Analysis, Current Alzheimer Research 2016; 13 (3) . https://dx.doi.org/10.2174/156720501303160217111434
DOI https://dx.doi.org/10.2174/156720501303160217111434 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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