Chemistry and Biology of Chromatin Remodeling Agents: State of Art and Future Perspectives of HDAC Inhibitors

Title: Chemistry and Biology of Chromatin Remodeling Agents: State of Art and Future Perspectives of HDAC Inhibitors

Volume: 13 Issue: 10

Author(s): Manuela Rodriquez, Maurizio Aquino, Ines Bruno, Giovanni De Martino, Maurizio Taddei and Luigi Gomez-Paloma

Affiliation:

Keywords: Epigenetic therapy, Histone deacetylase, Histone acetyltransferase, HDAC inhibitors, Antitumor, Apoptosis, Chromatin remodeling agents

Abstract: Chromatin remodeling is a fundamental phenomenon in the life of eukaryotic cells, bearing implications to numerous physiological and pathological phenomena. This review outlines the chemistry of natural and synthetic agents endowed with the ability to interfere with such biological function, with a particular emphasis on histone deacetylase (HDAC) inhibitors. Other aspects covered in this article comprise structure activity relationships (SAR) and modes of action at molecular level, including the description of crystal structures of enzyme-inhibitor complexes.

Cite this article as:

Rodriquez Manuela, Aquino Maurizio, Bruno Ines, Martino De Giovanni, Taddei Maurizio and Gomez-Paloma Luigi, Chemistry and Biology of Chromatin Remodeling Agents: State of Art and Future Perspectives of HDAC Inhibitors, Current Medicinal Chemistry 2006; 13 (10) . https://dx.doi.org/10.2174/092986706776360905