摘要
降钙素基因相关肽(CGRP)广泛分布于中枢和外周神经系统,已被证明是一个具有37个氨基酸的多功能神经肽,参与多种生理和病理过程。最近,有越来越多的证据表明在非神经细胞也存在CGRP,如上皮细胞、内皮细胞、内皮祖细胞(EPCs)、T淋巴细胞、B淋巴细胞、外周血单个核细胞(PBMC)和脂肪细胞。CGRP的在非神经组织中的存在是非常重要的,其可通过不同的途径调控多种生理和病理过程,特别是通过自分泌或旁分泌的方式。 本文整合最近的进展结果,旨在为非神经来源的CGRP及其对生理和病理过程的有关影响提供新的见解。
关键词: 脂肪细胞,CGRP,内皮细胞,内皮祖细胞,上皮细胞,肝细胞,免疫细胞。
Current Medicinal Chemistry
Title:An Overview of Non-Neural Sources of Calcitonin Gene-Related Peptide
Volume: 23 Issue: 8
Author(s): Rong Hu, Yuan-Jian Li and Xiao-Hui Li
Affiliation:
关键词: 脂肪细胞,CGRP,内皮细胞,内皮祖细胞,上皮细胞,肝细胞,免疫细胞。
摘要: Calcitonin gene-related peptide (CGRP) is extensively distributed throughout the central and peripheral nervous systems and has been shown to be a 37 amino acid multifunctional neuropeptide involved in a wide range of physiological and pathological processes. Recently, there is increasing evidence suggesting that CGRP also exists in non-nerve cells, such as epithelial cells, endothelial cells, endothelial progenitor cells (EPCs), T lymphocytes, B lymphocytes, peripheral blood mononuclear cells (PBMCs), and adipocytes. The existence of CGRP in non-neural tissue is of great importance to the regulation of multiple physiological and pathological processes via different pathways, especially through an autocrine/paracrine mode. This review integrates evidence from recent developments and aims to provide novel insights into non-neural sources of CGRP and its effects on physiological and pathological processes.
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Cite this article as:
Rong Hu, Yuan-Jian Li and Xiao-Hui Li , An Overview of Non-Neural Sources of Calcitonin Gene-Related Peptide, Current Medicinal Chemistry 2016; 23 (8) . https://dx.doi.org/10.2174/0929867323666160210125416
DOI https://dx.doi.org/10.2174/0929867323666160210125416 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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