抗甲型H1N1流感病毒成药化合物的研究进展

Title:Fight Against H1N1 Influenza A Virus: Recent Insights Towards the Development of Druggable Compounds

Volume: 23 Issue: 18

Author(s): Michele Tonelli and Elena Cichero

Affiliation:

关键词: 甲型流感（H1N1）病毒，药物设计，M2离子通道阻滞剂，HA抑制剂，NA抑制剂，RNA聚合酶复合体抑制剂。

摘要: In this review we discuss drug design strategies directed to the development of potential anti-influenza A(H1N1) inhibitors of M2 ion channel, neuraminidase (NA), hemagglutinin (HA) and RNA-dependent RNA-polymerase complex (RdRp) major targets, following temporal chronology of their findings. Besides searching for new chemotypes, eventually active against new targets of influenza A (H1N1), the design of optimized analogues of proven drugs is largely pursued, taking into account the emerging insight into the mechanisms of resistance to existing antivirals. Computational studies are also summarized, in order to highlight the structural requirements for further chemical optimizations.

Cite this article as:

Michele Tonelli and Elena Cichero , Fight Against H1N1 Influenza A Virus: Recent Insights Towards the Development of Druggable Compounds, Current Medicinal Chemistry 2016; 23 (18) . https://dx.doi.org/10.2174/0929867323666160210124930