摘要
入侵导致转移的形成是肿瘤标志之一。不同人类肿瘤的分析导致PPFIA1基因编码一种癌症可能的表演者liprin-α1蛋白。PPFIA1基因在恶性肿瘤中是放大的,包括20%的乳腺癌肿瘤。同时liprin-α1蛋白在肿瘤中也是过度表达。liprin-α1蛋白属于细胞质基质liprin蛋白家族。细胞质基质蛋白包括4个liprin-α,两个成员liprin-β和liprin-γ/kazrinE。在这篇综述中,我们将讨论家族中不同成员角色在肿瘤细胞迁移和入侵区别方面的证据。体外研究证据暗示着过度表达的liprin-α1蛋白控制着人类乳腺癌细胞的迁移和入侵。蛋白影响细胞迁移和入侵通过控制两种与细胞侵入相关的板状伪足和侵入伪足结构的形成。liprin-α1在细胞中,形成与liprin-β1, ERC1/ELKS and LL5一种复杂的蛋白,它位于迁移细胞和明确地控制板状伪足稳定性和整合的调整粘着斑。另一方面, liprin-β2似乎扮演一个角色通过抑制乳腺癌细胞的能动性和入侵作为肿瘤抑制。可用的数据表明liprin在肿瘤细胞入侵的规定中是核心球员,因此对反转移治疗显示作用。
关键词: 乳腺癌,细胞运动性,黏着斑,入侵
图形摘要
Current Cancer Drug Targets
Title:Role of Liprins in the Regulation of Tumor Cell Motility and Invasion
Volume: 16 Issue: 3
Author(s): Sara Chiaretti and Ivan de Curtis
Affiliation:
关键词: 乳腺癌,细胞运动性,黏着斑,入侵
摘要: Invasion leading to the formation of metastasis is one of the hallmarks of cancer. Analysis of different human cancers has led to the identification of the PPFIA1 gene encoding the protein liprin-α1, a possible player in cancer. The PPFIA1 gene is amplified in malignant tumors, including about 20% of breast cancers. Also the liprin-α1 protein is found overexpressed in tumors. Liprin-α1 belongs to the liprin family of cytosolic scaffold proteins that includes four liprin-α, two liprin-β members, and liprin-γ/kazrinE. In this review we will discuss the available evidence on the role of different members of the liprin family in distinct aspects of tumor cell migration and invasion. Evidence from in vitro studies indicates that the widely expressed liprin-α1 protein regulates the migration and invasion of human breast cancer cells. Liprin-α1 affects cell migration and invasion by regulating the organization of lamellipodia and invadopodia, two structures relevant to cell invasion. In the cell liprin-α1 forms a complex with liprin-β1, ERC1/ELKS and LL5 proteins, which localizes at the front of migrating cells and positively regulates lamellipodia stability, and integrin–mediated focal adhesions. On the other hand, liprin-β2 appears to play a role as tumor suppressor by inhibiting breast cancer cell motility and invasion. The available data indicate that liprins are central players in the regulation of tumor cell invasion, therefore representing interesting targets for anti-metastatic therapy.
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Cite this article as:
Sara Chiaretti and Ivan de Curtis , Role of Liprins in the Regulation of Tumor Cell Motility and Invasion, Current Cancer Drug Targets 2016; 16 (3) . https://dx.doi.org/10.2174/156800961603160206124103
DOI https://dx.doi.org/10.2174/156800961603160206124103 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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