Abstract
Polyhydroxylated alkaloids are frequently found in living systems. More than hundred compounds have been isolated from plants and microorganisms. Besides their utility as powerful tools in fundamental studies of the catalytic mechanism of glycosidases and glycosyltransferases, many natural polyhydroxylated alkaloids represent potential therapeutic agents. Due to the fact that very few compounds are commercially available a tremendous effort has been made to establish valuable synthetic approaches. This report which is not intended to be exhaustive is aimed at highlighting the progress in the synthetic methods that have appeared in the literature the last seven years concerning elaboration of natural polyhydroxylated pyrrolidines, piperidines, pyrrolizidines and indolizidines.
Keywords: Iminosugars, glycosyltransferases, polyhydroxylated, pyrrolidines, piperidines, pyrrolizidines, indolizidines
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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