Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel

Title:Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel

Volume: 16 Issue: 7

Author(s): Jianwei Li, Anping Li, Minghua Li, Yufeng Qiao and Hui Zhang

Affiliation:

Keywords: Larotaxel, taxanes, synthesis, MCF-7, cytotoxicity, breast cancer.

Abstract: Two epimeric metabolites of Larotaxel were synthesized in eight steps from 10-DAB III as a commercial material and their structures were characterized using NMR and MS spectral data. The cytotoxicity of two metabolites was performed on breast cancer cell lines MCF-7, MX-1 and MDA-MB-231. It is remarkable that both of these two desired taxanes showed great potent cytotoxic effect.

Cite this article as:

Li Jianwei, Li Anping, Li Minghua, Qiao Yufeng and Zhang Hui, Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (7) . https://dx.doi.org/10.2174/1871520616666160201151344