Neuroinflammation is Associated with Brain Extracellular TAU-Protein Release After Spontaneous Subarachnoid Hemorrhage

Title:Neuroinflammation is Associated with Brain Extracellular TAU-Protein Release After Spontaneous Subarachnoid Hemorrhage

Volume: 18 Issue: 12

Author(s): Alois Josef Schiefecker*, Anelia Dietmann, Ronny Beer, Bettina Pfausler, Peter Lackner, Mario Kofler, Marlene Fischer, Gregor Broessner, Florian Sohm, Miriam Mulino, Claudius Thomé, Christian Humpel, Erich Schmutzhard and Raimund Helbok

Affiliation:

• Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck,Austria

Keywords: Neuroinflammation, tau protein, intracerebral hemorrhage, interleukin-6, cerebral microdialysis.

Abstract: Introduction: Animal data suggest an association between neuroinflammation and secondary brain injury including axonal injury after aneurysmal subarachnoid hemorrhage (aSAH). We sought to study the association between brain extracellular interleukin (IL)-6 and TAU-protein levels as a surrogate marker for neuroinflammation and axonal injury in patients with poor grade aSAH.

Methods: Prospectively collected data from 26 consecutive poor-grade aSAH patients with multimodal neuromonitoring including cerebral microdialysis (CMD) were retrospectively analyzed. IL-6 and TAU-protein levels were analyzed using ELISA from a single CMD-sample every 24 hours and correlated with brain metabolic and hemodynamic parameters. Patients were dichotomized to highgrade (N=10) or low-grade (N=16) neuroinflammation according to their median CMD-IL-6 levels. Data were analyzed using generalized estimating equations to account for multiple within-subject measurements.

Results: Perilesional probe location (P=0.02) and aSAH related intracerebral hemorrhage (aICH) volume (P=0.003) at admission were associated with high-grade neuroinflammation. Brain extracellular TAU-protein levels (P=0.001), metabolic distress and delayed cerebral infarction (DCI; P=0.001) were linked to high-grade neuroinflammation. Relative or absolute phosphor-TAU levels were not correlated with CMD-IL-6 levels. High-grade neuroinflammation was a predictor for worse outcome three months after ictus, independently from probe location, initial Hunt&Hess grade and age (P=0.01).

Conclusion: Neuroinflammation after aSAH is associated with intraparenchymal bleeding, deranged cerebral metabolism and TAU-protein release. The impact of potential anti-inflammatory treatment strategies on secondary brain injury after aSAH has to be investigated in future studies.

Cite this article as:

Schiefecker Josef Alois*, Dietmann Anelia, Beer Ronny, Pfausler Bettina, Lackner Peter, Kofler Mario, Fischer Marlene, Broessner Gregor, Sohm Florian, Mulino Miriam, Thomé Claudius, Humpel Christian, Schmutzhard Erich and Helbok Raimund, Neuroinflammation is Associated with Brain Extracellular TAU-Protein Release After Spontaneous Subarachnoid Hemorrhage, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450117666160201111804

DOI https://dx.doi.org/10.2174/1389450117666160201111804	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592