摘要
背景:有证据表明,单核苷酸多态性rs405509的T等位基因作为载脂蛋白E(APOE)启动子是阿尔茨海默病(AD)的危险因素。然而,目前尚不清楚大脑的自发活动的APOE-rs405509交互作用。方法:我们通过神经心理学测验和测量大脑默认模式网络(DMN)分析了非痴呆老年人rs405509TT等位基因和APOE ε4等位基因对认知功能的相互作用,由独立分量分析使用定义,基于静息状态的功能磁共振成像数据。结果:在一般精神状态、记忆和注意力中 rs405509 and APOE之间有显著的相互作用(P<0.05)。功能网络分析显示出在扣带回前部,内侧额叶区和楔前叶前部和后部DMN有显著 的APOE-rs405509互动(错误发现率P<0.05)。此外,在认知能力和DMN连通性之间被发现显著的相关性(P<0.05)。结论:数据表明,APOE-rs405509 通过脑功能网络作用损害老年人的认知功能。
关键词: 阿尔茨海默病,APOE ε4,默认模式网络,功能连接,rs405509。
Current Alzheimer Research
Title:The TT allele of rs405509 synergizes with APOE ε4 in the impairment of cognition and its underlying default mode network in non-demented elderly
Volume: 13 Issue: 6
Author(s): Chao Ma, Yangjun Zhang, Xin Li, Yaojing Chen, Junying Zhang, Zhen Liu, Kewei Chen, Zhanjun Zhang
Affiliation:
关键词: 阿尔茨海默病,APOE ε4,默认模式网络,功能连接,rs405509。
摘要: Background: Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 as the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer’s disease (AD). However, it is unclear the APOE-rs405509 interaction effect on brain spontaneous activity. Methods: We analyzed the interaction of the rs405509 TT allele and the APOE ε4 allele on cognitive performances measured using neuropsychological tests and brain default mode network (DMN) defined by independent component analysis using based on resting-state functional magnetic resonance imaging data among the non-demented elderly people. Results: Significant interaction was found between rs405509 and APOE on general mental status, memory and attention (p<0.05). Functional network analysis showed a significantly APOE-rs405509 interaction on anterior cingulate gyrus, medial frontal region and precuneus at anterior and posterior DMN (False Discovery Rate p<0.05). Additionally, significant correlations were found between cognitive performance and DMN connectivity (p<0.05). Conclusion: The data indicates that the APOE-rs405509 interaction impairs elderly’s cognitive performance through brain functional network.
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Cite this article as:
Chao Ma, Yangjun Zhang, Xin Li, Yaojing Chen, Junying Zhang, Zhen Liu, Kewei Chen, Zhanjun Zhang , The TT allele of rs405509 synergizes with APOE ε4 in the impairment of cognition and its underlying default mode network in non-demented elderly, Current Alzheimer Research 2016; 13 (6) . https://dx.doi.org/10.2174/1567205013666160129100350
DOI https://dx.doi.org/10.2174/1567205013666160129100350 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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