摘要
几种生物系统有牵连的双相情感障碍神经进展包括但不仅限于细胞因子水平、氧化应激标志物,单胺水平,色氨酸代谢和谷氨酸介导的兴奋性毒性,小胶质细胞的激活以及结构和功能的变化。患双相情感障碍个患者个体的经常性吸烟行为为探索共享和离散发病机制的研究提供了研究动力。除了可以导致死亡率增加,吸烟还可以激活一些在双相情感障碍的进展中有牵连的神经生物学效应系统。在这里,叙述性评论提供了双相障碍共病机制的证据和假定影响、烟草的使用、和尼古丁依赖、并讨论了这些相互作用的临床意义。
关键词: 生物标志物,双相情感障碍,尼古丁,氧化应激,吸烟。
Current Molecular Medicine
Title:The Adverse Effects of Smoking on Health Outcomes in Bipolar Disorder: A Review and Synthesis of Biological Mechanisms
Volume: 16 Issue: 2
Author(s): A. Slyepchenko, A.R. Brunoni, R.S. McIntyre, J. Quevedo and A.F. Carvalho
Affiliation:
关键词: 生物标志物,双相情感障碍,尼古丁,氧化应激,吸烟。
摘要: Several biological systems are implicated in the neuroprogression of bipolar disorder including but not limited to cytokine levels, oxidative stress markers, monoamine levels, tryptophan catabolite and glutamate-mediated excitotoxicity, microglial activation as well as structural and functional changes. The high rate of smoking behaviour in individuals with bipolar disorder provides the impetus for exploring shared and discrete pathogenetic mechanisms. In addition to contributing to increased mortality, smoking activates several neurobiological effector systems implicated in the progression of bipolar disorder. Here, a narrative review provides evidence and putative mechanisms of comorbid effects of BD, cigarette use, and nicotine dependence, and discusses the clinical implications of these interactions.
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Cite this article as:
A. Slyepchenko, A.R. Brunoni, R.S. McIntyre, J. Quevedo and A.F. Carvalho , The Adverse Effects of Smoking on Health Outcomes in Bipolar Disorder: A Review and Synthesis of Biological Mechanisms, Current Molecular Medicine 2016; 16 (2) . https://dx.doi.org/10.2174/1566524016666160126144601
DOI https://dx.doi.org/10.2174/1566524016666160126144601 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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