摘要
双相情感障碍(BD)是一种能使人衰弱的精神疾病,同时也是一个不断加重的全球公共健康问题。尽管双相情感障碍(BD)已经被概念化为一种神经进行性疾病,有一些证据建议在疾病的病理病因的神经发展通路起作用。关于围产期感染和双相情感障碍之间的风险相关证据的研究一直存在不一致性。在这里,我们对围生病原体与双相情感障碍的关系进行了系统的综述性研究。一种对PubMed、Embase、和psyinfo数据库的计算机化的文献检索到2015年1月31日开始实施。23项研究最终符合纳入标准。研究调查暴露于多种病原体,即巨细胞病毒(CMV),爱泼斯坦–巴尔病(EBV)、单纯疱疹病毒-1(HSV-1)、单纯疱疹病毒-2(HSV-2)、人类疱疹病毒-6(HHV-6),弓形虫,流感和水痘-带状疱疹病毒(VZV)。总体而言,研究提供了多种证据。因此,与精神分裂症不同、围产期感染作为BD的危险因素的作用仍然是不确定的。大量有前景的设计研究表明,其对阐明预曝光对于BD的一个潜在的危险因素传染性致病原的作用是必要的。
关键词: 双相情感障碍,母体感染,疱疹,流感,弓形虫,系统评价。
Current Molecular Medicine
Title:Exposure to Perinatal Infections and Bipolar Disorder: A Systematic Review
Volume: 16 Issue: 2
Author(s): T. Barichello, M. Badawy, M.R. Pitcher, P. Saigal, J.S. Generoso, J.A. Goularte, L.R. Simoes, J. Quevedo and A.F. Carvalho
Affiliation:
关键词: 双相情感障碍,母体感染,疱疹,流感,弓形虫,系统评价。
摘要: Bipolar disorder (BD) is a debilitating psychiatric disorder and a growing global public health issue. Notwithstanding BD has been conceptualized as a neuroprogressive illness, there are some evidences to suggest a role for neurodevelopmental pathways in the patho-etiology of this disorder. Evidences on the associations between perinatal infections and risk for bipolar disorder have been inconsistent across studies. Here, we performed a systematic review of observational studies on the relationship between exposure to perinatal pathogens and bipolar disorder. A computerized literature search of the PubMed, Embase, and PsyINFO databases till January 31st, 2015 was performed. Twenty-three studies ultimately met inclusion criteria. Studies investigated exposure to several pathogens namely Cytomegalovirus (CMV), Epstein–Barr Virus (EBV), Herpes simplex virus-1 (HSV-1), Herpes simplex virus-2 (HSV-2), Human herpesvirus 6 (HHV-6), Toxoplasma gondii, Influenza, and Varicella zoster virus (VZV). Overall, studies provided mixed evidences. Thus, contrary to schizophrenia, the role of perinatal infections as risk factors for BD remain inconclusive. Larger studies with a prospective design would be necessary to elucidate the role of previous exposure to infectious agents as a potential risk factor for BD.
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T. Barichello, M. Badawy, M.R. Pitcher, P. Saigal, J.S. Generoso, J.A. Goularte, L.R. Simoes, J. Quevedo and A.F. Carvalho , Exposure to Perinatal Infections and Bipolar Disorder: A Systematic Review, Current Molecular Medicine 2016; 16 (2) . https://dx.doi.org/10.2174/1566524016666160126143741
DOI https://dx.doi.org/10.2174/1566524016666160126143741 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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