Abstract
This article will review the techniques used for the characterization of the N-linked oligosaccharides of glycoproteins to be used in enzyme replacement therapy (ERT), describe the specific role some of these oligosaccharides play in the delivery of these enzymes and outline the syntheses of some relevant fluorogenic and chromogenic carbohydrates that are not commercially available. Without being extensive, this review is meant to provide adequate and relevant background literature and hopes to stimulate organic chemists to find creative solutions for problems associated with glycoproteins, and those faced by biochemists, bioanalytical and protein purification scientists.
Keywords: synthetic substrates, enzyme replacement therapy, mucopolysaccharidosis, chromogenic carbohydrates
Current Organic Chemistry
Title: The Significance of Carbohydrate Analyses and the Role of Synthetic substrates in Enzyme Replacement Therapy (ERT) with Special Reference to Mucopolysaccharidosis
Volume: 8 Issue: 6
Author(s): Falguni Dasgupta, R. Irene Masada, Philip L. Alferness, Michael Vellard and William S. Prince
Affiliation:
Keywords: synthetic substrates, enzyme replacement therapy, mucopolysaccharidosis, chromogenic carbohydrates
Abstract: This article will review the techniques used for the characterization of the N-linked oligosaccharides of glycoproteins to be used in enzyme replacement therapy (ERT), describe the specific role some of these oligosaccharides play in the delivery of these enzymes and outline the syntheses of some relevant fluorogenic and chromogenic carbohydrates that are not commercially available. Without being extensive, this review is meant to provide adequate and relevant background literature and hopes to stimulate organic chemists to find creative solutions for problems associated with glycoproteins, and those faced by biochemists, bioanalytical and protein purification scientists.
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Cite this article as:
Dasgupta Falguni, Masada Irene R., Alferness L. Philip, Vellard Michael and Prince S. William, The Significance of Carbohydrate Analyses and the Role of Synthetic substrates in Enzyme Replacement Therapy (ERT) with Special Reference to Mucopolysaccharidosis, Current Organic Chemistry 2004; 8 (6) . https://dx.doi.org/10.2174/1385272043485819
DOI https://dx.doi.org/10.2174/1385272043485819 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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