The Structure-Activity Relationship of Glycosaminoglycans and Their Analogues with β-Amyloid Peptide

Title:The Structure-Activity Relationship of Glycosaminoglycans and Their Analogues with β-Amyloid Peptide

Volume: 23 Issue: 4

Author(s): Xiang Zhou and Lan Jin

Affiliation:

Keywords: Alzheimer’s disease, β-amyloid peptide, glycosaminoglycans, structure-activity relationship.

Abstract: Alzheimer’s disease (AD) is a serious neurodegenerative disorder. β-amyloid peptide (Aβ) aggregation is believed to be the major cause of the disease. The process of Aβ aggregation can be enhanced by sulfated glycosaminoglycans. However, cell experiments have shown that sulfated glycosaminoglycan oligosaccharides or analogues may have significant neuroprotective properties and could inhibit the aggregation by competitive inhibition. The length and species of oligosaccharides or analogues can inhibit the toxicity of Aβ by inducing conformational changes of proteins in different manners. This review presents the conformational changes of Aβ in the presence of glycosaminoglycan, glycosaminoglycan oligosaccharides and analogues. The review might be helpful to comprehend the mechanism of β-amyloid fibrillations and the aggregation process.

Cite this article as:

Zhou Xiang and Jin Lan, The Structure-Activity Relationship of Glycosaminoglycans and Their Analogues with β-Amyloid Peptide, Protein & Peptide Letters 2016; 23 (4) . https://dx.doi.org/10.2174/0929866523666160115131517

DOI https://dx.doi.org/10.2174/0929866523666160115131517	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305