摘要
肾损害可由缺血、自身免疫性疾病、高血压、移植排斥反应、代谢或遗传性疾病、感染或毒素引起。这些因素的影响可能导致急性肾损伤(AKI)定义为尿量和肾功能突然下降,或鼓励慢性肾脏疾病(CKD)的发展。在尿和血清中测定的肾功能的生物标志物,以估计肾损伤的严重程度和性质而增加使用,因此适用于适当的治疗,并提高病人的管理。确定的生物标志物的值可以建议肾脏疾病和肾损伤的类型的潜在风险,预测疾病的进展,以及有助于评估应用治疗的反应。虽然新的生物标志物在实际使用中,血清肌酐,肾小球滤过率的指标仍然是最常用的肾功能的生物标志物,尽管它已知的局限性。近几十年来,许多研究结果发现尿和血清蛋白,可以作为早期和准确的AKI生物标志物检测及其发展,以及CKD的识别。本文综述了肾脏疾病中最重要的肾生物标志物的概述,分为以下类型:功能性生物标志物,上调蛋白,酶,和周期阻滞生物标志物。它描述了它们的属性与生理作用,并讨论了这些分子在不同的临床设置的效用。
关键词: 急性肾脏病,慢性肾脏病,周期阻滞的生物标志物,酶标记物、功能性生物标志物,肾毒性,上调蛋白。
Current Medicinal Chemistry
Title:Biochemical Markers of Renal Function
Volume: 23 Issue: 19
Author(s): Danijela Krstic, Nenad Tomic, Branimir Radosavljevic, Natasa Avramovic, Vesna Dragutinovic, Sanja Radojevic Skodric and Mirjana Colovic
Affiliation:
关键词: 急性肾脏病,慢性肾脏病,周期阻滞的生物标志物,酶标记物、功能性生物标志物,肾毒性,上调蛋白。
摘要: Kidney damage can be induced by ischemia, autoimmune diseases, hypertension, allograft rejection, metabolic or genetic disorders, infections or toxins. The influence of these factors could result in acute kidney injury (AKI) defined as an unexpected decrease in urine output or renal function, or encourage the development of chronic kidney disease (CKD). Biomarkers of renal function, measured in urine and serum, are in increasing use in order to estimate the severity and nature of kidney injury, and consequently apply appropriate therapy and improve patient management. The determined values of biomarkers can suggest the potential risk of kidney disease and the type of renal injury, predict the disease progression, as well as be helpful for assessing the response to an applied therapy. Although novel biomarkers are in practical use, serum creatinine, the indicator of glomerular filtration rate is still the most frequently used biomarker of renal function despite its known limitations. In recent decades, numerous studies resulted in discovering urinary and serum proteins that can serve as biomarkers for early and accurate detection of AKI and its development, as well as the identification of CKD. This review gives an overview of the most important renal biomarkers investigated in kidney diseases, classified in following types: functional biomarkers, up-regulated proteins, enzymes, and cycle arrest biomarkers. It describes their properties, physiological roles, and discusses the utility of these molecules in different clinical settings.
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Danijela Krstic, Nenad Tomic, Branimir Radosavljevic, Natasa Avramovic, Vesna Dragutinovic, Sanja Radojevic Skodric and Mirjana Colovic , Biochemical Markers of Renal Function, Current Medicinal Chemistry 2016; 23 (19) . https://dx.doi.org/10.2174/0929867323666160115130241
DOI https://dx.doi.org/10.2174/0929867323666160115130241 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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