Historical Hallmarks of Anticoagulation and Antiplatelet Agents

Title:Historical Hallmarks of Anticoagulation and Antiplatelet Agents

Volume: 22 Issue: 13

Author(s): Gregory Tsoucalas, Jacques Chevallier, Marianna Karamanou, Theodoros Papaioannou, Markos Sgantzos and George Androutsos

Affiliation:

Keywords: Anticoagulants, antiplatelets, thrombosis, history of medicine.

Abstract: Thrombosis is a well known phenomenon among physicians since antiquity. A variety of peculiar agents, such as leeches and bark, were used to prevent it. Hirudin was used during the 19th century. The next eon, heparin, strepokinase, urokinase, TPA, dicumarol, warfarin, aspirin, ticlopidine, Clopidogrel, SSHA and SP54 provoked huge advances in anticoagulation. During 21st century with the use of fondaparinux, dabigatran, rivaroxaban and Ticagrelor antithrombotic prevention and therapeutic interaction entered an era of medical challenges. Although the risk after a thrombotic episode is now highly reduced, blood clots still present damaging or even lethal consequences in human organisms and further research is strongly recommended.

Cite this article as:

Tsoucalas Gregory, Chevallier Jacques, Karamanou Marianna, Papaioannou Theodoros, Sgantzos Markos and Androutsos George, Historical Hallmarks of Anticoagulation and Antiplatelet Agents, Current Pharmaceutical Design 2016; 22 (13) . https://dx.doi.org/10.2174/1381612822666160111124615