Recent Progress in the Synthesis of Epothilones

Ruzhou      Zhang; Zhiyu      Liu

doi:10.2174/1385272043485927

Abstract

Epothilones exhibit high antitumor activities with the same mechanism of action as Taxol and retain a much greater toxicity against p-glycoprotein overexpressing multiple drug resistant (MDR) cells. The realization of their unique potential as antitumor agents resulted in an intense race for their total synthesis, structure modification, and biological investigation. Recently a wealth of new chemistry has been developed in the synthesis of epothilone family. This review will present recent progress in the syntheses of epothilones and analogues.

Keywords: Epothilones, p-glycoprotein, Taxol

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Current Organic Chemistry

Title: Recent Progress in the Synthesis of Epothilones

Volume: 8 Issue: 4

Author(s): Ruzhou Zhang and Zhiyu Liu

Affiliation:

Keywords: Epothilones, p-glycoprotein, Taxol

Abstract: Epothilones exhibit high antitumor activities with the same mechanism of action as Taxol and retain a much greater toxicity against p-glycoprotein overexpressing multiple drug resistant (MDR) cells. The realization of their unique potential as antitumor agents resulted in an intense race for their total synthesis, structure modification, and biological investigation. Recently a wealth of new chemistry has been developed in the synthesis of epothilone family. This review will present recent progress in the syntheses of epothilones and analogues.

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Zhang Ruzhou and Liu Zhiyu, Recent Progress in the Synthesis of Epothilones, Current Organic Chemistry 2004; 8 (4) . https://dx.doi.org/10.2174/1385272043485927