摘要
迷走神经刺激(VNS)已广泛用于治疗各种神经系统疾病,尤其是癫痫。越来越多的证据也表明其在抗抑郁治疗中的应用潜力,因为VNS被几个临床试验证实对缓解抑郁和降低抑郁症患者的复发风险的长期影响。同样,VNS也证明抑郁模型大鼠行为障碍的改善。虽然VNS对单胺类神经递质代谢和改善情绪的影响是公认的,潜在的机制介导其抗抑郁作用仍知之甚少。最近的研究结果表明,VNS增强增殖的海马神经祖细胞(NPCs)和突触传递可能作为一个独立的途径有利于单胺类VNS对抑郁症的有利影响。在这里,我们简要地回顾了近年来在该领域的进展,并在此基础上提出的,也有可能至少两个重叠,但互动途径介导的VNS的抗抑郁作用。
关键词: 迷走神经刺激、抑郁、神经发生、海马、单胺、脑源性神经营养因子。
Current Molecular Medicine
Title:Vagus nerve stimulation in treating depression: A tale of two stories.
Volume: 16 Issue: 1
Author(s): T.-F. Yuan, A. Li, X. Sun, O. Arias-Carrión and S. Machado
Affiliation:
关键词: 迷走神经刺激、抑郁、神经发生、海马、单胺、脑源性神经营养因子。
摘要: Vagus nerve stimulation (VNS) has been widely used to treat different neurological disorders, especially epilepsy. Accumulating evidence also suggests its potential application in antidepressive therapy, given that VNS has been confirmed by several clinical trials to exert long-term effects on mitigating depression and reducing the risk of relapse in depressed patients. Likewise, VNS has also proven to ameliorate the behavioral deficits in a rat model of depression. While the influences of VNS on monoamine metabolism and mood improvement are well-recognized, the underlying mechanisms mediating its antidepressive action remain poorly understood. Recent findings suggest that VNS-enhanced proliferation of hippocampal neural progenitor cells (NPCs) and synaptic transmission might serve as a monoamine-independent pathway contributive to the beneficial effects of VNS on depression. Here we briefly reviewed the recent progress in this field, based on which we propose that there might be, at least, two little-overlapped, and yet interactive pathways mediating the antidepressive action of VNS.
Export Options
About this article
Cite this article as:
T.-F. Yuan, A. Li, X. Sun, O. Arias-Carrión and S. Machado , Vagus nerve stimulation in treating depression: A tale of two stories., Current Molecular Medicine 2016; 16 (1) . https://dx.doi.org/10.2174/1566524016666151222143609
DOI https://dx.doi.org/10.2174/1566524016666151222143609 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Natural Medicine:The Genus Angelica
Current Medicinal Chemistry Structure of Glutamate Receptors
Current Drug Targets From Blood-to-Brain: Regulating the Permeability of the Blood-Brain Barrier
Current Psychopharmacology Signaling Pathways that Regulate Basal ABC Transporter Activity at the Blood- Brain Barrier
Current Pharmaceutical Design The Brain Protective Effect of rTMS (Repetitive Transcranial Magnetic Stimulation) in Depression: A Mini-Review in Animal Studies
Medicinal Chemistry Chvostek's Sign in Paediatric Practice
Current Pediatric Reviews Statins, Mevalonate Pathway and its Intermediate Products in Placental Development and Preeclampsia
Current Molecular Pharmacology Herbal Medicine in the Treatment of Epilepsy
Current Drug Targets A Review on Biological Activities and Chemical Synthesis of Hydrazide Derivatives
Current Medicinal Chemistry The Effects of Hydroalcoholic Extract of Pinus eldarica on Hippocampal Tissue Oxidative Damage in Pentylenetetrazole-Induced Seizures in Rat
Current Nutrition & Food Science Neuroprotection by Natural Polyphenols: Molecular Mechanisms
Central Nervous System Agents in Medicinal Chemistry Ion Channel Defects in Idiopathic Epilepsies
Current Pharmaceutical Design Potassium Channels: Novel Emerging Biomarkers and Targets for Therapy in Cancer
Recent Patents on Anti-Cancer Drug Discovery Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects
Current Alzheimer Research The Role of Folate-supplementation in Depression: A Narrative Review
Current Psychopharmacology Drug Trials in Dementia: Challenging Ethical Dilemmas
Current Alzheimer Research In Silico Validation and Structure Activity Relationship Study of a Series of Pyridine-3-carbohydrazide Derivatives as Potential Anticonvulsants in Generalized and Partial Seizures
Central Nervous System Agents in Medicinal Chemistry Relevance of Breast Cancer Resistance Protein to Brain Distribution and Central Acting Drugs: A Pharmacokinetic Perspective
Current Drug Metabolism Metabolism of Drugs Used in the Therapy of Seizures: An Analytical Point of View. Part 1
Current Drug Metabolism Repurposed Drugs for the Treatment of Schizophrenia and Bipolar Disorders
Current Topics in Medicinal Chemistry