摘要
迷走神经刺激(VNS)已广泛用于治疗各种神经系统疾病,尤其是癫痫。越来越多的证据也表明其在抗抑郁治疗中的应用潜力,因为VNS被几个临床试验证实对缓解抑郁和降低抑郁症患者的复发风险的长期影响。同样,VNS也证明抑郁模型大鼠行为障碍的改善。虽然VNS对单胺类神经递质代谢和改善情绪的影响是公认的,潜在的机制介导其抗抑郁作用仍知之甚少。最近的研究结果表明,VNS增强增殖的海马神经祖细胞(NPCs)和突触传递可能作为一个独立的途径有利于单胺类VNS对抑郁症的有利影响。在这里,我们简要地回顾了近年来在该领域的进展,并在此基础上提出的,也有可能至少两个重叠,但互动途径介导的VNS的抗抑郁作用。
关键词: 迷走神经刺激、抑郁、神经发生、海马、单胺、脑源性神经营养因子。
Current Molecular Medicine
Title:Vagus nerve stimulation in treating depression: A tale of two stories.
Volume: 16 Issue: 1
Author(s): T.-F. Yuan, A. Li, X. Sun, O. Arias-Carrión and S. Machado
Affiliation:
关键词: 迷走神经刺激、抑郁、神经发生、海马、单胺、脑源性神经营养因子。
摘要: Vagus nerve stimulation (VNS) has been widely used to treat different neurological disorders, especially epilepsy. Accumulating evidence also suggests its potential application in antidepressive therapy, given that VNS has been confirmed by several clinical trials to exert long-term effects on mitigating depression and reducing the risk of relapse in depressed patients. Likewise, VNS has also proven to ameliorate the behavioral deficits in a rat model of depression. While the influences of VNS on monoamine metabolism and mood improvement are well-recognized, the underlying mechanisms mediating its antidepressive action remain poorly understood. Recent findings suggest that VNS-enhanced proliferation of hippocampal neural progenitor cells (NPCs) and synaptic transmission might serve as a monoamine-independent pathway contributive to the beneficial effects of VNS on depression. Here we briefly reviewed the recent progress in this field, based on which we propose that there might be, at least, two little-overlapped, and yet interactive pathways mediating the antidepressive action of VNS.
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Cite this article as:
T.-F. Yuan, A. Li, X. Sun, O. Arias-Carrión and S. Machado , Vagus nerve stimulation in treating depression: A tale of two stories., Current Molecular Medicine 2016; 16 (1) . https://dx.doi.org/10.2174/1566524016666151222143609
DOI https://dx.doi.org/10.2174/1566524016666151222143609 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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