骨髓间充质干细胞在黑色素瘤中的应用：一种潜在的靶向药物治疗方法。

Title:Application of Mesenchymal Stem Cells in Melanoma: A Potential Therapeutic Strategy for Delivery of Targeted Agents

Volume: 23 Issue: 5

Author(s): Hamed Mirzaei, Amirhossein Sahebkar, Amir Avan, Mahmoud R. Jaafari, Rasoul Salehi, Hossein Salehi, Hossein Baharvand and Abbas Rezaei, Jamshid Hadjati, John M. Pawelek, Hamid R. Mirzaei

Affiliation:

关键词: 黑色素瘤，骨髓间充质干细胞，靶向抗癌疗法，恶性肿瘤，化疗耐药。

摘要: Melanoma is a leading cause of mortality from skin cancer and has a poor prognosis. Despite rapid advances in the treatment of this tumor type, the efficacy of current chemo-/targeted-therapies is still limited owing to the lack of sufficient drug accumulation in the tumor tissue and development of chemo-resistance. Recently, the application of mesenchymal stem cells (MSCs) in cancer therapy has gained substantial attention, suggesting their potential roles as an intriguing vehicle in improving the delivery of targeted agents. MSCs are genetically modified with suicide tumor suppressor genes to inhibit cell signaling pathways associated with the progression and metastatic features of melanoma. Here we describe the clinical application of MSCs in melanoma with a particular emphasis on recent findings on the role of MSC expressing a distinct set of biologically functional chemokines and tumor suppressing agents. Accumulating data has shown the tumor- oriented homing capacity of MSCs and their applications as a vehicle (e.g., adipose derived mesenchymal stem cells expressing TRAIL, interferon-α/γ, pigment epithelium-derived factor and cytosine deaminase). Several questions regarding possible potential and intrinsic mechanisms that might induce tumorigenesis and drug resistance are yet to be addressed for tailoring MSC-nbased treatment of melanoma.

Cite this article as:

Hamed Mirzaei, Amirhossein Sahebkar, Amir Avan, Mahmoud R. Jaafari, Rasoul Salehi, Hossein Salehi, Hossein Baharvand and Abbas Rezaei, Jamshid Hadjati, John M. Pawelek, Hamid R. Mirzaei , Application of Mesenchymal Stem Cells in Melanoma: A Potential Therapeutic Strategy for Delivery of Targeted Agents, Current Medicinal Chemistry 2016; 23 (5) . https://dx.doi.org/10.2174/0929867323666151217122033