Abstract
The prime roles of mutations in the genes, encoding chloride ion channels, in various human diseases of muscle, kidney, bone and brain, such as congenital myotonia, myotonic dystrophy, cystic fibrosis, osteopetrosis, epilepsy, glioma, etc., have been well established. Chloride ion channels are also responsible for glioma progression in brain and malaria parasite in red blood cells. The present article thus emphasises on the various diseases associated with chloride channel regulation and their modulators. Studies on various chloride channels and their modulators have been discussed in detail.
Keywords: Chloride ion channels, Chloride channel modulators, Cystic fibrosis transmembrane conductance regulator, Ligand-gated chloride channels.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Studies on Chloride Channels and their Modulators
Volume: 16 Issue: 16
Author(s): Vaishali M. Patil and Satya P. Gupta
Affiliation:
Keywords: Chloride ion channels, Chloride channel modulators, Cystic fibrosis transmembrane conductance regulator, Ligand-gated chloride channels.
Abstract: The prime roles of mutations in the genes, encoding chloride ion channels, in various human diseases of muscle, kidney, bone and brain, such as congenital myotonia, myotonic dystrophy, cystic fibrosis, osteopetrosis, epilepsy, glioma, etc., have been well established. Chloride ion channels are also responsible for glioma progression in brain and malaria parasite in red blood cells. The present article thus emphasises on the various diseases associated with chloride channel regulation and their modulators. Studies on various chloride channels and their modulators have been discussed in detail.
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Cite this article as:
M. Patil Vaishali and P. Gupta Satya, Studies on Chloride Channels and their Modulators, Current Topics in Medicinal Chemistry 2016; 16 (16) . https://dx.doi.org/10.2174/1568026616666151215104302
DOI https://dx.doi.org/10.2174/1568026616666151215104302 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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