摘要
全球范围内,胃癌是导致与癌症相关的死亡的第二大主要原因。胃癌被发现时往往是晚期,对其治疗已困难。早期发现胃癌的生物标志物和治疗胃癌的药物靶点是对胃癌有效治疗的关键。分泌蛋白不仅在肿瘤的进展和转移中发挥着不可或缺的作用,而且易于获得。因此,肿瘤微环境中的分泌蛋白是引起关注的生物标志物和药物靶点的来源。在这项研究中,用基于iTRAQ的液相色谱/串联质谱法比较分析11胃癌细胞株和正常胃上皮细胞株的分泌蛋白质组谱。与正常细胞相比,在一个或多个胃癌细胞株检测到接近800种蛋白质,检测到约600种蛋白质显示差异表达。这些差异表达的蛋白主要有结合或酶活性,主要与细胞和代谢过程相关。确认了胃癌细胞株ARPC4的过度表达,并在体外证实胃癌细胞的迁移和侵袭的新功能。本研究的结果支持ARPC4作为转移性胃癌的潜在生物标志物和药物靶点的见解。
关键词: ARPC4,胃癌,分泌蛋白质组,迁移,侵袭。
图形摘要
Current Cancer Drug Targets
Title:Comparative Proteomic Profiling of Extracellular Proteins between Normal and Gastric Cancer Cells
Volume: 16 Issue: 5
Author(s): Mulina Kang, Ssuyi Lu, Poh Kuan Chong, Khay Guan Yeoh, Yoon Pin Lim
Affiliation:
关键词: ARPC4,胃癌,分泌蛋白质组,迁移,侵袭。
摘要: Gastric cancer is the second leading cause of cancer-related deaths worldwide. Gastric cancer is often detected at a late stage when treatment is difficult. Biomarkers for early detection and drug targets for gastric cancer therapy are critical for effective management of gastric cancer. Secreted proteins not only play integral roles in cancer progression and metastasis, they are also easily accessible. Secreted proteins within the tumor microenvironment are therefore an attractive source of biomarkers and drug targets. In this study, iTRAQ-based liquid chromatography/tandem mass spectrometry was used for comparative profiling of the secretomes of 11 gastric cancer cell lines versus a normal gastric epithelial cell line. Of the close to 800 proteins detected, about 600 proteins were detected to display differential expression in one or more gastric cancer cell lines compared to normal cells. These differentially expressed proteins predominantly have binding or enzymatic activities and are largely associated with cellular and metabolic processes. Overexpression of ARPC4 was validated in gastric cell lines and its novel function in gastric cancer cell migration and invasion demonstrated in vitro. The findings support the notion of ARPC4 as a potential biomarker/drug target for metastatic gastric cancer.
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Cite this article as:
Mulina Kang, Ssuyi Lu, Poh Kuan Chong, Khay Guan Yeoh, Yoon Pin Lim , Comparative Proteomic Profiling of Extracellular Proteins between Normal and Gastric Cancer Cells, Current Cancer Drug Targets 2016; 16 (5) . https://dx.doi.org/10.2174/1568009616666151209113606
DOI https://dx.doi.org/10.2174/1568009616666151209113606 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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