摘要
肛门激酶(JAK2)是一种非受体酪氨酸激酶信号分子,它能调控各种激素和细胞因子,包括干扰素、促红细胞生成素、瘦素和生长激素的影响。它也有促进肿瘤生长,修饰营养转运的活性。JAK2基因有助于细胞容积调节、在消耗能量时保护细胞和增加肿瘤细胞的存活率。最近,JAK2基因被确定为跨膜运输过程的一个强有力的调节器。JAK2直接或间接的刺激或抑制转运蛋白,包括离子通道、载体和Na+/K+泵。作为细胞膜转运的调控器,JAK2调节各种各样离子通道如钾、钙、钠、氯和多Na +耦合细胞载体,其中,多Na +耦合细胞载体包括EAAT1-4, NaPi-IIa, SGLT1, BoaT1, PepT1-2, CreaT1, SMIT1, BGT1和 Na+/K+-ATPase。这些细胞运输有利于各种生理、病理过程,从而发挥JAK2敏感效应。未来的研究将确定JAK2基因调是否节细胞表面其他转运体的表达并进一步阐明JAK2起作用的重要机制。
关键词: 载体、细胞运输、激素、离子通道、JAK2、Na+/K+泵。
Current Medicinal Chemistry
Title:The Relevance of JAK2 in the Regulation of Cellular Transport
Volume: 23 Issue: 6
Author(s): Mentor Sopjani, Vjollca Konjufca, Mark Rinnerthaler, Rexhep Rexhepaj, Miribane Dërmaku-Sopjani
Affiliation:
关键词: 载体、细胞运输、激素、离子通道、JAK2、Na+/K+泵。
摘要: Janus kinase-2 (JAK2) is a non-receptor tyrosine kinase signaling molecule that mediates the effects of various hormones and cytokines, including interferon, erythropoietin, leptin, and growth hormone. It also fosters tumor growth and modifies the activity of several nutrient transporters. JAK2 contributes to the regulation of the cell volume, protectS cells during energy depletion, proliferation, and aids the survival of tumor cells. Recently, JAK2 was identified as a powerful regulator of transport processes across the plasma membrane. Either directly or indirectly JAK2 may stimulate or inhibit transporter proteins, including ion channels, carriers and Na+/K+ pumps. As a powerful regulator of transport mechanisms across the cell membrane, JAK2 regulates a wide variety of potassium, calcium, sodium and chloride ion channels, multiple Na+-coupled cellular carriers including EAAT1-4, NaPi-IIa, SGLT1, BoaT1, PepT1-2, CreaT1, SMIT1, and BGT1 as well as Na+/K+-ATPase. These cellular transport regulations contribute to various physiological and pathophysiological processes and thus exerting JAK2-sensitive effects. Future investigations will be important to determine whether JAK2 regulates cell-surface expression of other transporters and further elucidate underlying mechanisms governing JAK2 actions.
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Mentor Sopjani, Vjollca Konjufca, Mark Rinnerthaler, Rexhep Rexhepaj, Miribane Dërmaku-Sopjani , The Relevance of JAK2 in the Regulation of Cellular Transport, Current Medicinal Chemistry 2016; 23 (6) . https://dx.doi.org/10.2174/0929867323666151207111707
DOI https://dx.doi.org/10.2174/0929867323666151207111707 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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