摘要
博莱霉素(BLM)尽管是治疗癌症最有效的广谱化疗药物之一,但是已经由于它们较弱的药物传递能力和导致肺纤维化的副作用而在临床应用中受限。随着治疗的增加和副作用的减少,BLM靶向给药系统(TDDS)的研究与开对于扩展基于BLM治疗药物临床应用是有必要的。本文综述了BLMS各种TDDS的研究进展,包括如光化学内化、超声和胶束、脂质体的纳米颗粒的形成。概述了每个给药方法的优点和缺点以及与每个给药系统相关的特定挑战。
关键词: 博莱霉素;电化学;脂质体;微球;纳米粒子;光化学内化;靶向给药;超声
图形摘要
Current Cancer Drug Targets
Title:Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review
Volume: 16 Issue: 6
Author(s): Zhiqiang Yu, Bo Yan, Liqian Gao, Chenbo Dong, Jian Zhong, Mathew D'Ortenzio, Brandon Nguyen, Su Seong Lee, Xianglong Hu and Feng Liang
Affiliation:
关键词: 博莱霉素;电化学;脂质体;微球;纳米粒子;光化学内化;靶向给药;超声
摘要: Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug delivery abilities, and the side effect of causing lung fibrosis. With the increased therapeutics and the reduction of side effects, research and development of targeted drug delivery systems (TDDS) with BLMs have become essential for the expansive clinical usage of BLM-based therapeutics. This review summarizes the recent developments of various TDDS for BLMs, including techniques such as photochemical internalization, ultrasound, and micelle, liposome, and nanoparticle formation. The advantages and disadvantages for each delivery approach are outlined, along with the specific challenges associated with each delivery system.
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Zhiqiang Yu, Bo Yan, Liqian Gao, Chenbo Dong, Jian Zhong, Mathew D'Ortenzio, Brandon Nguyen, Su Seong Lee, Xianglong Hu and Feng Liang , Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review, Current Cancer Drug Targets 2016; 16 (6) . https://dx.doi.org/10.2174/1568009616666151130213910
DOI https://dx.doi.org/10.2174/1568009616666151130213910 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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