摘要
心血管疾病(CVD)是导致死亡的主要原因。普遍认为,氧化应激在心血管疾病发展过程中起着关键作用。因此,氧化损伤可能被抗氧化剂所阻止。多酚是一类具有抗氧化特性而被广泛研究的植物化学成分。这些化合物的主要来源包括水果、蔬菜、坚果、香草、可可、茶和咖啡。流行病学研究表明,饮食富含多酚类的蔬菜和心血管疾病患病率的减少有关。这可能与多酚类化合物的抗炎、抗血栓和血管舒张作用有关。即使这些生物效应可能主要归因于多酚的抗氧化活性,但也应考虑其其他的药理机制。后者可能包括直接的抗炎作用,细胞内信号转导和基因表达调控、一氧化氮代谢的改善,以及血小板聚集。评估的多酚类化合物的干预措施没有表现出与观测研究报告相同的阳性结果。目前,关于茶多酚预防心血管疾病的实际效果仍存在争议。因此,加强对多酚药代动力学的研究,以及更好地了解这些化合物的作用机制是大有裨益的。
关键词: 多酚,心血管疾病预防,血管扩张,炎症,血栓形成,动脉粥样硬化。
Current Medicinal Chemistry
Title:Potential Role of Polyphenols in the Prevention of Cardiovascular Diseases: Molecular Bases
Volume: 23 Issue: 2
Author(s): Juan Guillermo Gormaz, Nicolas Valls, Camilo Sotomayor, Thomas Turner and Ramón Rodrigo
Affiliation:
关键词: 多酚,心血管疾病预防,血管扩张,炎症,血栓形成,动脉粥样硬化。
摘要: Cardiovascular diseases (CVD) are the leading cause of mortality worldwide. It is widely accepted that oxidative stress plays a key role in their development and progression; hence oxidative damage might be abrogated by antioxidants. Polyphenols are phytochemicals showing extensively studied antioxidant properties in-vivo. Most representative sources of these compounds include fruits, greens, nuts, herbs, cocoa, tea and coffee. Epidemiological evidence suggests an association between the consumption of polyphenol-rich vegetables and the reduction of cardiovascular disease prevalence. This fact could be related to the anti-inflammatory, antithrombotic and vasodilatory effects of polyphenols. Even though these biological effects could be mainly attributed to the antioxidant activity of polyphenols, other pharmacological mechanisms should also be considered. The latter could comprise direct anti-inflammatory effects, modulation of intracellular signaling and gene expression, improvement of nitric oxide homeostasis, as well as platelet antiaggregation. However, it is noticeable that protocols of interventions to evaluate the properties of polyphenols have failed to show the same positive results reported from observational studies. At present, a controversy exists regarding the actual effectiveness of polyphenols in preventing cardiovascular diseases. Therefore, an improvement of the available knowledge about polyphenol pharmacokinetics, together with a better understanding of the mechanisms of action of these compounds, could be of great benefit. Thus, a rational support for the development of interventional designs could provide reliable evidence on the actual role of polyphenols in CVD prevention.
Export Options
About this article
Cite this article as:
Juan Guillermo Gormaz, Nicolas Valls, Camilo Sotomayor, Thomas Turner and Ramón Rodrigo , Potential Role of Polyphenols in the Prevention of Cardiovascular Diseases: Molecular Bases, Current Medicinal Chemistry 2016; 23 (2) . https://dx.doi.org/10.2174/0929867323666151127201732
DOI https://dx.doi.org/10.2174/0929867323666151127201732 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Squalene as Novel Food Factor
Current Pharmaceutical Biotechnology Vitamins in the Prevention or Delay of Cognitive Disability of Aging
Current Aging Science Mechanical Design and Control Method for SEA and VSA-based Exoskeleton Devices for Elbow Joint Rehabilitation
Neuroscience and Biomedical Engineering (Discontinued) Phytoestrogen-Rich Dietary Supplements in Anti-Atherosclerotic Therapy in Postmenopausal Women
Current Pharmaceutical Design Chemotherapy and Cardiotoxicity in Hematologic Malignancies
Current Cancer Drug Targets Editorial Statins: [Hot Topic: Statins: Effects Beyond Cholesterol Lowering (Guest Editor: Garry X. Shen)]
Current Drug Targets - Cardiovascular & Hematological Disorders Short Term, Low Dose Simvastatin Pretreatment Alters Memory Immune Function Following Secondary Staphylococcus aureus Infection
Current Pharmaceutical Biotechnology The Multimodal Treatment of Acromegaly: Current Status and Future Perspectives
Endocrine, Metabolic & Immune Disorders - Drug Targets Novel Anticoagulants vs Warfarin for Stroke Prevention in Atrial Fibrillation
Cardiovascular & Hematological Disorders-Drug Targets High-Density Lipoprotein Quantity or Quality for Cardiovascular Prevention?
Current Pharmaceutical Design Insulin Resistance and Postprandial Hyperglycemia the Bad Companions in Natural History of Diabetes: Effects on Health of Vascular Tree
Current Diabetes Reviews VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina
Current Alzheimer Research Direct Cardiac Reprogramming with Engineered miRNA Scaffolds
Current Pharmaceutical Design Plant Polyphenols and Oral Health: Old Phytochemicals for New Fields
Current Medicinal Chemistry Protein Oxidative Modification in the Aging Organism and the Role of the Ubiquitin Proteasomal System
Current Pharmaceutical Design Genistein as a Potential Anticancer Agent Against Head and Neck Squamous Cell Carcinoma
Current Topics in Medicinal Chemistry Emerging Approved Treatments for Idiopathic Pulmonary Fibrosis: Some Hope for Patients?
Current Respiratory Medicine Reviews Alzheimers Disease Burdens African-Americans: A Review of Epidemiological Risk Factors and Implications for Prevention and Treatment
Current Psychiatry Reviews Acute Passivation of Vulnerable Plaques with Wild-Type Apolipoprotein A-I in ApoE-Deficient Mice
Vascular Disease Prevention (Discontinued) Complications of Diabetes: An Insight into Genetic Polymorphism and Role of Insulin
Recent Patents on Inflammation & Allergy Drug Discovery