Abstract
A discussion of 1-hydroxypyranonaphthoquinones is presented that outlines the isolation and biological activity of the known naturally occurring members of this class of compounds. Synthetic approaches developed towards 1- hydroxypyranonaphthoquinones and analogues having potentially improved biological profiles are discussed with particular emphasis on the HRV 3C-protease inhibitor thysanone.
Keywords: 1-hydroxy-1H-benzo[g]isochromene, 1-hydroxy-1H-naphtho[2, 3-c]pyran, fungal pigment, HRV 3C-protease, lactol, naphthopyran, pyranonaphthoquinone, thysanone.
Graphical Abstract
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