Chronic Inflammatory Diseases: Progress and Prospect with Herbal Medicine

Title:Chronic Inflammatory Diseases: Progress and Prospect with Herbal Medicine

Volume: 22 Issue: 2

Author(s): Nilanjan Ghosh, Asif Ali, Rituparna Ghosh, Shaileyee Das, Subhash C. Mandal and Mahadeb Pal

Affiliation:

Keywords: Inflammation, natural products, nuclear factor kappa B (NF-κB), toll like receptor (TLR), cytokines, interleukin.

Abstract: Diseases associated with chronic inflammatory pathology claim a major share of worldwide deaths each year. A principal reason behind the huge number of casualties is associated with mild or unnoticed symptoms for long period of time since the outset, and that specific treatment options for these diseases have not yet emerged. Current anti-inflammatory drugs essentially have become ineffective for long term protection from these diseases as they also interfere with essential cellular pathways and associated toxicities. Notably, recent studies with a number of phytochemicals have shown promising results. These compounds isolated from various medicinal plants express their anti-inflammatory activities by down regulating expression of several crucial pro-inflammatory mediators. These are mostly antioxidants; inhibit induction of key transcription factors like nuclear factor kappa B (NF-κB) that are responsible for expression of proinflammatory mediators, and other growth regulators. Definitely, some of these compounds have the potential to be developed into new therapeutic agents to better control inflammation associated diseases in near future. This review summarizes recent findings on the molecular mechanisms through which various inflammatory activities are linked to disease progression and a group of natural products that have shown promise in controlling these processes.

Cite this article as:

Ghosh Nilanjan, Ali Asif, Ghosh Rituparna, Das Shaileyee, Mandal C. Subhash and Pal Mahadeb, Chronic Inflammatory Diseases: Progress and Prospect with Herbal Medicine, Current Pharmaceutical Design 2016; 22 (2) . https://dx.doi.org/10.2174/1381612822666151112151419