大肠癌的细胞色素P450 2W1（CYP2W1）

Title:Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers

Volume: 16 Issue: 1

Author(s): Felicia Fei-Lei Chung, Chun Wai Mai, Pei Yuen Ng and Chee-Onn Leong

Affiliation:

关键词: 癌症治疗，大肠癌，细胞色素P450第2家族W亚族的第1多肽（CYP2W1），细胞色素P450，前体药物

摘要: Cytochrome P450, family 2, subfamily W, polypeptide 1 (CYP2W1) is a newly identified monooxygenase enzyme that is expressed specifically in tumor tissues and during fetal life. Particularly, high expression of CYP2W1 was observed in up to 60% of colorectal cancers and its expression correlated with poor survival. CYP2W1 has been shown to metabolize various endogenous substrates including lysophospholipids and several procarcinogens, such as polycyclic aromatic hydrocarbon. The specific substrate for CYP2W1, however, is currently unknown. Due to its tumor-specific expression and its unique catalytic activities in colorectal cancers, CYP2W1 was deemed as an interesting target in colorectal cancer therapy. This review sought to summarize the current understanding of the CYP2W1 biology and biochemistry, its genetic polymorphisms and cancer risk, and its implication as a tumor-specific diagnostic and therapeutic target.

Cite this article as:

Felicia Fei-Lei Chung, Chun Wai Mai, Pei Yuen Ng and Chee-Onn Leong , Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers, Current Cancer Drug Targets 2016; 16 (1) . https://dx.doi.org/10.2174/1568009616888151112095948