Improved, High Yield Synthesis of 3H-Quinazolin-4-ones, the Key Intermediates of Recently Developed Drugs

Title: Improved, High Yield Synthesis of 3H-Quinazolin-4-ones, the Key Intermediates of Recently Developed Drugs

Volume: 11 Issue: 19

Author(s): Laszlo Orfi, Frigyes Waczek, Janos Pato, Istvan Varga, Balint Hegymegi-Barakonyi, Richard A. Houghten and Gyorgy Ker

Affiliation:

Keywords: pyrimidines, quinazolin-4-ones, formamidine-acetate, imidoyl-chlorides, purine analogs, protein kinase inhibitors, antiproliferative agents, phosphodiesterase v inhibitors

Abstract: Purine bases and their bioisosteric analogs are widely used as building blocks in combinatorial chemistry. Recently a great number of fused pyrimidine derivatives became known as potential drug molecules against various types of proliferative diseases, caused by over-expression of protein kinases [1]. One of the most important compound

Cite this article as:

Orfi Laszlo, Waczek Frigyes, Pato Janos, Varga Istvan, Hegymegi-Barakonyi Balint, Houghten A. Richard and Ker Gyorgy, Improved, High Yield Synthesis of 3H-Quinazolin-4-ones, the Key Intermediates of Recently Developed Drugs, Current Medicinal Chemistry 2004; 11 (19) . https://dx.doi.org/10.2174/0929867043364423