摘要
衰老涉及生理功能的逐步恶化,削弱了个体生存的能力。事实上,衰老是癌症、糖尿病、心血管疾病和神经退行性疾病的主要危险因素。发现老化的速率是由保守的遗传和生化途径控制的,其在老化研究领域中代表了一个前所未有的进步。AMPK蛋白作为一个有效的控制因素,是一种代谢传感器并控制能量平衡和抗应力。因此,通过正确的调节这一因素来提高健康状态和生存质量。在这篇文章中我们将回顾分子途径AMPK是衰老过程相关的控制,特别要注意线粒体功能障碍,代谢放松管制、细胞衰老与细胞自噬。
关键词: AMPK、衰老、代谢紊乱、氧化应激、衰老。
图形摘要
Current Drug Targets
Title:AMPK Function in Aging Process
Volume: 17 Issue: 8
Author(s): Rocío Ruiz, Eva María Pérez-Villegas, Ángel Manuel Carrión
Affiliation:
关键词: AMPK、衰老、代谢紊乱、氧化应激、衰老。
摘要: Aging involves the progressive deterioration of physiological functions, diminishing the individual’s capacity for survival. Indeed, aging is the main risk factor for cancer, diabetes, cardiovascular disorders and neurodegenerative diseases. The discovery that the rate of aging is controlled by conserved genetic and biochemical pathways represented an unprecedented advance in aging research. The AMPK protein is a metabolic sensor that acts as a qualified cellular housekeeper, as well as controlling energy homeostasis and resistance to stress. Thus, the correct regulation of this factor enhances health and survival. In this manuscript we will review the molecular pathways regulated by AMPK that are related to the aging process, paying special attention to mitochondrial dysfunction, metabolic deregulation, cell senescence and autophagy.
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Cite this article as:
Rocío Ruiz, Eva María Pérez-Villegas, Ángel Manuel Carrión , AMPK Function in Aging Process, Current Drug Targets 2016; 17 (8) . https://dx.doi.org/10.2174/1389450116666151102095825
DOI https://dx.doi.org/10.2174/1389450116666151102095825 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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