摘要
虽然钻瘤运动存在于传染性肝病,钻瘤运动在慢性乙型肝炎的诊断价值并不完全清楚。本研究的目的是评估钻瘤运动在慢性肝炎B的组织学特征和实验室参数。共402例乙型肝炎等肝脏疾病患者进行回顾性评估处理。乙型肝炎炎症的严重程度由评分系统评价。荧光免疫进行染色, CD8 T细胞,CD20(B细胞)、CD56(NK细胞)、CD68(巨噬细胞)和MPO(中性粒细胞)。钻瘤运动可在74.0%慢性乙型肝炎(慢乙肝)患者和82.8%的急性乙型肝炎患者(AHB)观察到。在钻瘤运动中,CD8 + T细胞是主要的细胞类型。在慢性乙肝患者钻瘤运动炎症活动的得到高分。在慢性乙肝患者中钻瘤运动出现较高的血清ALT,AST和GGT水平。患者HBV DNA负载钻瘤运动是那些没有钻瘤运动的10倍。HBeAb 与钻瘤运动的证据明显相关。在慢性乙型肝炎,钻瘤运动与肝损伤的严重程度有关。钻瘤运动的存在是一个活跃的肝脏炎症的指标。
关键词: Emperipolesis
Current Molecular Medicine
Title:Emperipolesis is a potential histological hallmark associated with chronic hepatitis B.
Volume: 15 Issue: 9
Author(s): Y. Hu, L. Jiang, G. Zhou, S. Liu, Y. Liu, X. Zhang, S. Zhao, L. Wu, M. Yang, L. Ma, X. Wang and J. Zhao
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关键词: Emperipolesis
摘要: Although emperipolesis exists in infectious liver diseases, the diagnostic value of emperipolesis in chronic hepatitis B is not exactly known. The aim of this study is to evaluate the histological characteristics and laboratory parameters of emperipolesis in chronic hepatitis B. Totally 402 patients with hepatitis B and other liver diseases were processed in a retrospective assessment. Inflammatory severity of hepatitis B was evaluated with Ishak Scoring System. Immunofluorescent staining was performed for CD8 (T cells), CD20 (B cells), CD56 (NK cells), CD68 (macrophages) and MPO (neutrophils). Emperipolesis was observed in 74.0% of patients with chronic hepatitis B (CHB) and 82.8% of patients with acute hepatitis B (AHB). In emperipolesis, CD8+ T cell was the main cell type. Patients with emperipolesis in CHB got high scores of inflammatory activity. Among patients with CHB, emperipolesis was present with higher serum ALT, AST and GGT levels. HBV DNA Load in patients with emperipolesis was as 10 times high as those without emperipolesis. HBeAb was significantly correlated with the evidence of emperipolesis. In chronic hepatitis B, emperipolesis was associated with severity of liver injury. The presence of emperipolesis was an indicator of active liver inflammation.
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Y. Hu, L. Jiang, G. Zhou, S. Liu, Y. Liu, X. Zhang, S. Zhao, L. Wu, M. Yang, L. Ma, X. Wang and J. Zhao , Emperipolesis is a potential histological hallmark associated with chronic hepatitis B., Current Molecular Medicine 2015; 15 (9) . https://dx.doi.org/10.2174/1566524015666151026105411
DOI https://dx.doi.org/10.2174/1566524015666151026105411 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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