摘要
胸腺细胞(TNCs)是特殊的上皮细胞,位于胸腺皮质。1980年的初始报告他们的发现表明(TNCs)内包含200胸腺细胞在细胞质中含有特殊的液泡。已经有很多报道从那时开始确定在(TNCs)和发展中胸腺细胞这种异形内化的作用。在本文中,我们讨论的文献报道,描述了细胞内化现象和(TNCs)在胸腺T细胞内化现象中扮演的角色,以及为什么这些多细胞复合物在抑制自身免疫性疾病的发展中可能扮演了重要的角色。
关键词: Thymic nurse cells
Current Molecular Medicine
Title:Thymic Nurse Cells Participate in Heterotypic Internalization and Repertoire Selection of Immature Thymocytes; Their Removal from the Thymus of Autoimmune Animals May be Important to Disease Etiology
Volume: 15 Issue: 9
Author(s): J. C. Guyden, M. Martinez, R. V.E. Chilukuri, V. Reid, F. Kelly and M. -O.D. Samms
Affiliation:
关键词: Thymic nurse cells
摘要: Thymic nurse cells (TNCs) are specialized epithelial cells that reside in the thymic cortex. The initial report of their discovery in 1980 showed TNCs to contain up to 200 thymocytes within specialized vacuoles in their cytoplasm. Much has been reported since that time to determine the function of this heterotypic internalization event that exists between TNCs and developing thymocytes. In this review, we discuss the literature reported that describes the internalization event and the role TNCs play during T cell development in the thymus as well as why these multicellular complexes may be important in inhibiting the development of autoimmune diseases.
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J. C. Guyden, M. Martinez, R. V.E. Chilukuri, V. Reid, F. Kelly and M. -O.D. Samms , Thymic Nurse Cells Participate in Heterotypic Internalization and Repertoire Selection of Immature Thymocytes; Their Removal from the Thymus of Autoimmune Animals May be Important to Disease Etiology, Current Molecular Medicine 2015; 15 (9) . https://dx.doi.org/10.2174/1566524015666151026102328
DOI https://dx.doi.org/10.2174/1566524015666151026102328 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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