摘要
从胚胎发育在成人体内平衡的维护,通过消除不必要的或突变细胞,细胞程序性死亡积极参与多种生物学过程。多个细胞死亡通路与细胞凋亡、坏死和细胞自噬一直是持续研究的热点。最近一个独特的细胞死亡通路称为“死亡cell-in-cell”被发现。与传统的细胞死亡通路相比,cell-in-cell死亡,主要特征为,一个细胞的死亡,是由另一个细胞入侵相邻细胞和激活独立溶酶体使细胞退化或激活独立细胞凋亡蛋白酶使细胞凋亡。在过去的几年里,cell-in-cell取得了惊人的进展,发现了,包括entosis,同类相食和emperitosis多个机制为cell-in-cell死亡的主要机制。一些关键问题仍有待解决,如特定的生化标记来精确区分不同cell-in-cell结构属性与生理和病理的相关性。在这种情况和兴趣的驱使下,这一领域的顶尖科学家打算从不同的模型系统cell-in-cell结构与读者分享当前研究进展。重点强调机制的研究进展,推测未来的研究方向。
关键词: Programmed cell death
Current Molecular Medicine
Title:Entosis and Related Forms of Cell Death within Cells.
Volume: 15 Issue: 9
Author(s): Y. Wang and X. -D. Wang
Affiliation:
关键词: Programmed cell death
摘要: By eliminating the unneeded or mutant cells, programmed cell death actively participates in a wide range of biological processes from embryonic development to homeostasis maintenance in adult. Continuing efforts have identified multiple cell death pathways, with apoptosis, necrosis and autophage the mostly studied. Recently a unique cell death pathway called “cell-in-cell death” has been defined. Unlike traditional cell death pathways, cell-in-cell death, characterized by cell death within another cell, is triggered by the invasion of one cell into its neighbor and executed by either lysosome-dependent degradation or caspase-dependent apoptosis. With remarkable progresses on cell-in-cell over past few years, multiple mechanisms, including entosis, cannibalism and emperitosis, are found to be responsible for cell-in-cell death. Some key questions, such as specific biochemical markers to distinguish precisely the properties of different cell-in-cell structures and the physiological and pathological relevance, remain to be addressed. In light of this situation and a surge of interests, leading scientists in this field intend to share with readers current research progresses on cell-in-cell structures from different model systems through this special edition on cell-in-cell. The mechanistic advances will be highlighted while the future researches be speculated.
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Cite this article as:
Y. Wang and X. -D. Wang , Entosis and Related Forms of Cell Death within Cells., Current Molecular Medicine 2015; 15 (9) . https://dx.doi.org/10.2174/1566524015666151026100339
DOI https://dx.doi.org/10.2174/1566524015666151026100339 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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