摘要
唐氏综合征的21号染色体,包含了被认为在AD的神经病理学的发展起关键作用的几个基因。21号染色体上淀粉样前体蛋白(APP)基因的过度表达,导致DS早发型β-淀粉样蛋白(Aβ)的斑块。除了Aβ的堆积,DS的中年患者进一步发展成神经原纤维缠结、脑血管病变、白质病变、氧化性损伤、神经炎症和神经元丢失。经足够的神经病理学诊断为AD后,也有在DS里有益于大脑的潜在的代偿性反应和延迟痴呆发生的证据。本综述介绍了DS现有的部分文献,也强调了我们对AD神经病理学的知识差距。发展网络化标准化的收集程序的大脑银行,以充分描述与老龄化相关的局部的和短暂的病理变化,这在未来将是至关重要的。随着越来越多关于AD的信息获取,将有机会制定对DS适龄的延迟AD发生的干预措施。
关键词: Beta-amyloid
Current Alzheimer Research
Title:Aging in Down Syndrome and the Development of Alzheimer’s Disease Neuropathology
Volume: 13 Issue: 1
Author(s): Elizabeth Head, Ira T. Lott, Donna M. Wilcock and Cynthia A. Lemere
Affiliation:
关键词: Beta-amyloid
摘要: Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to play a critical role in the development of AD neuropathology. The overexpression of the gene for the amyloid precursor protein (APP), on chromosome 21, leads to early onset beta-amyloid (Aβ) plaques in DS. In addition to Aβ accumulation, middle-aged people with DS develop neurofibrillary tangles, cerebrovascular pathology, white matter pathology, oxidative damage, neuroinflammation and neuron loss. There is also evidence of potential compensatory responses in DS that benefit the brain and delay the onset of dementia after there is sufficient neuropathology for a diagnosis of AD. This review describes some of the existing literature and also highlights gaps in our knowledge regarding AD neuropathology in DS. It will be critical in the future to develop networked brain banks with standardized collection procedures to fully characterize the regional and temporal pathological events associated with aging in DS. As more information is acquired regarding AD evolution in DS, there will be opportunities to develop interventions that are age-appropriate to delay AD in DS.
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Elizabeth Head, Ira T. Lott, Donna M. Wilcock and Cynthia A. Lemere , Aging in Down Syndrome and the Development of Alzheimer’s Disease Neuropathology, Current Alzheimer Research 2016; 13 (1) . https://dx.doi.org/10.2174/1567205012666151020114607
DOI https://dx.doi.org/10.2174/1567205012666151020114607 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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