物理增强技术的应用下，载药纳米/微系统药物局部和透皮给药

Title:Topical and Transdermal Delivery of Drug-Loaded Nano/ Microsystems with Application of Physical Enhancement Techniques

Volume: 17 Issue: 13

Author(s): Lívia Neves Borgheti-Cardoso, Tamara Ângelo, Guilherme M. Gelfuso, Renata F.V. Lopez, Taís Gratieri

Affiliation:

关键词: 树枝状聚合物，离子导入，脂质体，微针，纳米颗粒，渗透皮肤，超音波。

摘要: Topical and transdermal delivery has been studied over last decades and it presents advantages for the treatment of several disorders, macromolecules delivery and vaccination. The greatest challenge is to overcome the stratum corneum (SC) barrier. Compared to traditional topical formulation strategies, nano /microsystems offer advantages such as increased stability, increased loading dose, coverage of undesired colors, reduced toxicity and prolonged release of active agents. However, there are no conclusive studies demonstrating the ability of such systems to penetrate the skin in relevant therapeutic amounts. The use of physical methods holds great promise for enhancing skin permeation through the SC and for targeting hair follicles. This review discusses the characteristics and feasibility of using a dual approach employing the application of physical methods of permeation enhancement to enable the topical or transdermal delivery of drug-loaded nano/microsystems.

Cite this article as:

Lívia Neves Borgheti-Cardoso, Tamara Ângelo, Guilherme M. Gelfuso, Renata F.V. Lopez, Taís Gratieri , Topical and Transdermal Delivery of Drug-Loaded Nano/ Microsystems with Application of Physical Enhancement Techniques, Current Drug Targets 2016; 17 (13) . https://dx.doi.org/10.2174/1389450116666151019095121