Biologic Therapy in Inflammatory and Immunomediated Skin Diseases: Safety Profile

Title:Biologic Therapy in Inflammatory and Immunomediated Skin Diseases: Safety Profile

Volume: 11 Issue: 1

Author(s): Giulia Ganzetti, Anna Campanati, E. Molinelli and A. Offidani

Affiliation:

Keywords: Inflammation, immuno-mediated disease, anti-TNF-alpha, off-label use.

Abstract: Biologic treatments have modified the therapeutic armamentarium in the treatment of many dermatological and non- dermatological diseases and data on literature have widely focused on the efficacy and safety of TNF-alpha inhibitors in psoriasis.

Although the etiopathogenesis has not completely elucidated, inflammation appears the lait motif unifying the immune-pathogenesis of diverse skin disease, as atopic dermatitis, alopecia areata and hidradenitis suppurativa.

Actually, data on the off-label use of biologics in cutaneous immune-mediated inflammatory diseases are scarce and restricted to anecdotal cases and case series.

The present review aims to evidence the major off- label use of TNF-alpha inhibitors in dermatology.

Cite this article as:

Ganzetti Giulia, Campanati Anna, Molinelli E. and Offidani A., Biologic Therapy in Inflammatory and Immunomediated Skin Diseases: Safety Profile, Current Drug Safety 2016; 11 (1) . https://dx.doi.org/10.2174/1574886310666151014121732