Abstract
Metal carbene-involved C-H insertion reaction is among the most useful and efficient method for the construction of C-C bonds. While C(sp3)-H insertion and C(sp2)-H insertion have been intensively studied during the past several decades, C(sp)-H insertion of terminal alkynes with metal carbenes has only received great attention from the synthetic community recently. This cross-coupling reaction between terminal alkynes with different metal carbene precursors offers a versatile strategy for the synthesis of different types of alkynes or allenes, which are very useful synthetic intermediates in organic synthesis. This type of cross-coupling reaction, in which a migratory insertion step of alkynylsubstituted metal carbene species is generally involved, also offers new opportunities for the development of related cascade or multicomponent reactions.
Keywords: Terminal alkyne, cross-coupling, metal carbene, migratory insertion, diazo compound, N-Tosylhydrazone, allene, C(sp)-H insertion.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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