Abstract
In the recent years, so-called cell-penetrating peptides (CPPs) have been in constant study due to its ability to penetrate cell membranes. CCPs are characterized by a length of less than 60 amino acids, its highly cationic nature and by a positive net charge at neutral pH. For the CPPs either an endocytic or non-endocytic uptake mechanism has been identified. This work presents the computational polarity index method that is able to predict the uptake mechanism of CPPs with an accuracy of 72% in a double-blind test. This was achieved by reading the peptide sequence and measuring the polarity as one single physico-chemical property. The method was verified by extracting all peptides from the CPPsite database (April 21, 2014) and its efficiency was tested with seven specialized databases of peptides and proteins.
Keywords: Polarity index method, cell-penetrating peptides, endocytic pathway, non-endocytic pathway.
Current Bioinformatics
Title:Identification of Uptake Mechanism of Cell-Penetrating Peptides by their Polar Profile
Volume: 10 Issue: 5
Author(s): Carlos Polanco, José Lino Samaniego Mendoza, Thomas Buhse, Jorge Alberto Castañón González, Arturo Gimbel and Marili Leopold Sordo
Affiliation:
Keywords: Polarity index method, cell-penetrating peptides, endocytic pathway, non-endocytic pathway.
Abstract: In the recent years, so-called cell-penetrating peptides (CPPs) have been in constant study due to its ability to penetrate cell membranes. CCPs are characterized by a length of less than 60 amino acids, its highly cationic nature and by a positive net charge at neutral pH. For the CPPs either an endocytic or non-endocytic uptake mechanism has been identified. This work presents the computational polarity index method that is able to predict the uptake mechanism of CPPs with an accuracy of 72% in a double-blind test. This was achieved by reading the peptide sequence and measuring the polarity as one single physico-chemical property. The method was verified by extracting all peptides from the CPPsite database (April 21, 2014) and its efficiency was tested with seven specialized databases of peptides and proteins.
Export Options
About this article
Cite this article as:
Polanco Carlos, Samaniego Mendoza Lino José, Buhse Thomas, Alberto Castañón González Jorge, Gimbel Arturo and Sordo Leopold Marili, Identification of Uptake Mechanism of Cell-Penetrating Peptides by their Polar Profile, Current Bioinformatics 2015; 10 (5) . https://dx.doi.org/10.2174/1574893610666151008011903
DOI https://dx.doi.org/10.2174/1574893610666151008011903 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial (Thematic Issue: Chemoresistance in Gynecologic Cancers)
Current Cancer Therapy Reviews Machine Learning in Healthcare
Current Genomics Research Progress of Exogenous Plant MiRNAs in Cross-Kingdom Regulation
Current Bioinformatics State of Research Tracks and Property Protection of Photodynamic Sensitizers and Delivery Methodologies
Recent Patents on Chemical Engineering Anticancer Peptides and Proteins: A Panoramic View
Protein & Peptide Letters Exploration of Chemopreventive Potential of Linalool in Targeting Lung Cancer Biomarkers
Endocrine, Metabolic & Immune Disorders - Drug Targets A Comprehensive Review on Exosomes and Microvesicles as Epigenetic Factors
Current Stem Cell Research & Therapy The Use of Innovative Tools to Reproduce Human Cancer Translocations: Lessons from the CRISPR/Cas System
Current Biotechnology Pentraxins and Atherosclerosis: The Role of PTX3
Current Pharmaceutical Design Bladder Cancer: A Simple Model Becomes Complex
Current Genomics Liposome-Nanogel Structures for Future Pharmaceutical Applications: An Updated Review
Current Pharmaceutical Design Are KRAS/BRAF Mutations Potent Prognostic and/or Predictive Biomarkers in Colorectal Cancers?
Anti-Cancer Agents in Medicinal Chemistry Modular Organization in a Cell: Concepts and Applications
Current Bioinformatics Matching Chelators to Radiometals for Positron Emission Tomography Imaging- Guided Targeted Drug Delivery
Current Drug Targets Clinical and Genetic Features of Warts, Hypogammaglobulinemia, Infections and Myelokathexis (WHIM) Syndrome
Current Molecular Medicine HIV-1 Vpr: A Closer Look at the Multifunctional Protein from the Structural Perspective
Current HIV Research Monoterpenes as Perspective to Chronic Pain Management: A Systematic Review
Current Drug Targets Astatine Radiopharmaceuticals: Prospects and Problems
Current Radiopharmaceuticals Codon Swapping of Zinc Finger Nucleases Confers Expression in Primary Cells and <i>In Vivo</i> from a Single Lentiviral Vector
Current Gene Therapy Synthesis of Cinnamide Dimers as Potential Antibacterial and Antifungal Agents
Letters in Drug Design & Discovery