摘要
对传统抗肿瘤药物的耐药性是影响肿瘤治疗失败的主要原因之一。在肿瘤中发现了2种对抗肿瘤药物耐药的主要类型,即固有耐药性,其肿瘤细胞对化疗有固有的抵抗力,并获得耐药性,这是以往的药物揭示的结果。抗肿瘤细胞对化疗药物的抗药性成为对与抗肿瘤药物相似和结构无关的交叉耐药性,生物机制被称为多药耐药(MDR)。在被认为可以克服多药耐药性的策略中,载体介导的药物管理是一种创新的和有前途的替代方式。在本综述中,我们报告了一些纳米载体包括聚合物–药物偶联物,聚合物胶束,纳米管,LBL纳米胶囊,和二氧化硅和金纳米颗粒。这些系统的设计是为了蒽环类药物,有效传递长花春碱,紫杉烷类药物,和其他药物的高效传递。这些为了专门克服多药耐药性和它们的作用机制纳米载体的发展已被研究讨论。最后,我们讨论了以化疗方案为基础并通过为了多种物质的传递的纳米载体的设计来逆转肿瘤细胞多药耐药的纳米载体长远发展的挑战和机遇。
关键词: 抗癌治疗,耐药的癌症,纳米药物输送,ROS敏感的纳米药物,核酸递送,多药耐药性,近红外响应纳米药物。
Current Medicinal Chemistry
Title:Engineering Nanomedicines to Overcome Multidrug Resistance in Cancer Therapy
Volume: 23 Issue: 1
Author(s): Giovanni L. Beretta and Francesca Cavalieri
Affiliation:
关键词: 抗癌治疗,耐药的癌症,纳米药物输送,ROS敏感的纳米药物,核酸递送,多药耐药性,近红外响应纳米药物。
摘要: Drug resistance to conventional antitumor drugs represents one of the major causes of treatment failure in patients affected by tumors. Two main types of drug resistance to anticancer drugs are found in tumors, namely intrinsic resistance, in which tumor cells are inherently resistant to chemotherapy, and acquired resistance, which results from previous drug exposure. Tumor cells resistant to a chemotherapeutic agent become cross-resistant to both similar and structurally unrelated classes of antitumor drugs, a biological mechanism known as multi drug resistance (MDR). Among the strategies considered to overcome MDR, nanovector-mediated drug administration represents an innovative and promising alternative. In this review, we report a number of nanovectors including polymer–drug conjugates, polymeric micelles, nanotubes, LbL nanocapsules, and silica and gold nanoparticles. These systems are designed for the efficient delivery of anthracyclines, vinca alkaloids, taxanes, and others drugs. The development of these nanovectos to specifically overcome MDR and their mechanisms of action are covered and discussed. Finally, we discuss challenges and opportunities for further development of nanodevices-based chemotherapies to circumvent MDR through the design of nanovectors for the delivery of multiple cargoes.
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Cite this article as:
Giovanni L. Beretta and Francesca Cavalieri , Engineering Nanomedicines to Overcome Multidrug Resistance in Cancer Therapy, Current Medicinal Chemistry 2016; 23 (1) . https://dx.doi.org/10.2174/0929867322666151006094559
DOI https://dx.doi.org/10.2174/0929867322666151006094559 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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