Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review

Title:Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review

Volume: 16 Issue: 2

Author(s): Bijo Mathew, Abitha Haridas, Jerad Suresh, Githa E. Mathew, Gülberk Uçar and Venkatesan Jayaprakash

Affiliation:

Keywords: Alzheimer's disease, Chalcones, Depression, MAO-A, MAO-B.

Abstract: Introduction: Chalcones are one of the major classes of naturally occurring compounds and have a vast significance in medicinal chemistry, presenting with a wide scope of pharmacological actions.

Discussion: The present review focused our attention onto the monoamine oxidase inhibitory activity of natural and synthetic chalcones. The review also emphasises the structure-activity relationship studies and molecular recognition of chalcones towards MAO-A and B inhibition.

Conclusion: Many of the studies clearly revealed that most of the chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A. Recent studies also showed that heteroaryl-based chalcones are potent MAO-A inhibitors.

Cite this article as:

Mathew Bijo, Haridas Abitha, Suresh Jerad, E. Mathew Githa, Uçar Gülberk and Jayaprakash Venkatesan, Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review, Central Nervous System Agents in Medicinal Chemistry 2016; 16 (2) . https://dx.doi.org/10.2174/1871524915666151002124443