摘要
基因治疗的发展的一个关键障碍仍然缺乏用于基因递送的安全、高效、易于控制的载体。关于病毒载体的基本问题,如缺乏特异性和免疫原性潜力,推动了非病毒基因递送系统的发展。在过去的十年中,p53基因替代疗法的研究在文献中处支配地位。虽然p53基因治疗的临床试验已经取得了有限的成功,但它仍然是癌症治疗临床试验正式评估的唯一的肿瘤抑制基因,而非病毒系统的递送越来越受到关注。本文特别回顾了目前非病毒方法的p53基因递送的研究,包括物理和化学的方法,尤其是后者。本文还讨论了目前成功的p53癌症基因治疗带来的机遇和挑战。
关键词: p53,基因治疗,非病毒载体,癌症,联合治疗。
Current Medicinal Chemistry
Title:Non-viral Delivery Systems for the Application in p53 Cancer Gene Therapy
Volume: 22 Issue: 35
Author(s): Kai Wang, Qian Huang, Fuming Qiu and Meihua Sui
Affiliation:
关键词: p53,基因治疗,非病毒载体,癌症,联合治疗。
摘要: A key barrier to the development of gene therapy remains the lack of safe, efficient and easily controllable vehicles for gene delivery. The fundamental problems associated with the viral vehicles, e.g. lack of specificity and immunogenic potential, have driven the development of non-viral systems of gene delivery. In the last decade, studies on p53 gene replacement therapy have dominated the literature. Although clinical trials of p53 gene therapy have achieved limited success, it remains the only tumor suppressor gene to be evaluated formally in clinical trials for cancer treatment, with increasing focus on delivery using non-viral systems. In this article, we particularly review current investigations on p53 gene delivery using non-viral methods, including both physical and chemical approaches, with an emphasis on the latter. The existing opportunities and challenges for successful p53 cancer gene therapy are also discussed.
Export Options
About this article
Cite this article as:
Kai Wang, Qian Huang, Fuming Qiu and Meihua Sui , Non-viral Delivery Systems for the Application in p53 Cancer Gene Therapy, Current Medicinal Chemistry 2015; 22 (35) . https://dx.doi.org/10.2174/0929867322666151001121601
DOI https://dx.doi.org/10.2174/0929867322666151001121601 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Inhibitors for Metastasis Development
Recent Patents on Anti-Cancer Drug Discovery The Epidemiology of Sepsis
Current Pharmaceutical Design Vanilloid Receptor Antagonists: Emerging Class of Novel Anti-Inflammatory Agents for Pain Management
Current Pharmaceutical Design Toxicities of Immunosuppressive Treatment of Autoimmune Neurologic Diseases
Current Neuropharmacology Celastrol Inhibits the Proliferation and Decreases Drug Resistance of Cisplatin- Resistant Gastric Cancer SGC7901/DDP Cells
Anti-Cancer Agents in Medicinal Chemistry The Concomitance of Hypertension and Diabetes Exacerbating Retinopathy: The Role of Inflammation and Oxidative Stress.
Current Clinical Pharmacology EDITORIAL [Hot Topic-II: PPAR Ligands and Cardiovascular Disorders: Friend or Foe (Guest Editors: Pitchai Balakumar and Gowraganahalli Jagadeesh)]
Current Molecular Pharmacology Olive Oil and Cancer Risk: an Update of Epidemiological Findings through 2010
Current Pharmaceutical Design Contemporary Review of Drugs Used to Treat Obesity
Cardiovascular & Hematological Agents in Medicinal Chemistry Gene Silencing in the Development of Personalized Cancer Treatment: The Targets, the Agents and the Delivery Systems
Current Gene Therapy The Genetic Landscapes of Inflammation-Driven Gastrointestinal Tract Cancers
Current Pharmaceutical Design Oncolytic Viruses: Programmable Tumour Hunters
Current Gene Therapy Novel Concepts in the Development of Platinum Antitumor Drugs
Current Medicinal Chemistry - Anti-Cancer Agents Bioactivities of Iridoids
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Tandem Multicomponent Reactions Toward the Design and Synthesis of Novel Antibacterial and Cytotoxic Motifs
Current Medicinal Chemistry Editorial [Hot Topic:Therapeutic Potential of Peptide Motifs - Part V (Executive Guest Editor: Jean-Claude Herve)]
Current Pharmaceutical Design Versatile Applications of microRNA in Anti-Cancer Drug Discovery: From Therapeutics to Biomarkers
Current Drug Discovery Technologies A Review on Synthetic and Natural Steroid Dimers: 1997-2006
Current Medicinal Chemistry Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon
Current Pharmaceutical Design Metallic Colloid Nanotechnology, Applications in Diagnosis and Therapeutics
Current Pharmaceutical Design