新的药理学方法预防心肌缺血 - 再灌注损伤

Title:New Pharmacological Approaches to the Prevention of Myocardial Ischemia- Reperfusion Injury

Volume: 18 Issue: 15

关键词: 心脏保护，缺血再灌注，抗氧化剂，活性氧，黄酮醇，硫化氢，腺苷，阿片样物质，肠降血糖素基治疗，环孢菌素A.

摘要: Background: Early reperfusion of the blocked vessel is critical to restore the blood flow to the ischemic myocardium to salvage myocardial tissue and improve clinical outcome. This reperfusion strategy after a period of ischemia, however, may elicit further myocardial damage named myocardial reperfusion injury. The manifestations of reperfusion injury include arrhythmias, myocardial stunning and micro-vascular dysfunction, in addition to significant cardiomyocyte death. It is suggested that an overproduction of reactive oxygen species, intracellular calcium overload and inflammatory cell infiltration are the most important features of myocardial ischemia-reperfusion injury.

Objective: In this review, various pharmacological interventions to treat myocardial reperfusion injury including the antioxidant flavonols, hydrogen sulfide, adenosine, opioids, incretin-based therapies and cyclosporin A which targets the mitochondrial permeability transition pore are discussed.

Conclusion: The processes involved in reperfusion injury might provide targets for improved outcomes after myocardial infarction but thus far that aim has not been met in the clinic.

Cite this article as:

New Pharmacological Approaches to the Prevention of Myocardial Ischemia- Reperfusion Injury, Current Drug Targets 2017; 18 (15) . https://dx.doi.org/10.2174/1389450116666151001112020