摘要
纳米技术和纳米药物是新兴的研究领域;它主要专注于创造与控制纳米级材料使其更好成像,诊断以及治疗一系列疾病,包括癌症。基于环糊精的纳米海绵,作为一个新型纳米输送体系,是三位网络中具有超交联性和开拓性的环糊精聚合物纳米结构。基于纳米海绵的体系有潜能提高溶解度,吸收率,渗透率,生物相容性,体内稳定性,靶向缓释性和许多抗癌药物的疗效。基于药物输送系统的纳米海绵扩展结合已有抗癌构想显著的克服了上述问题,这是未来癌症治疗进展中振奋人心的亟需的研究领域。这篇文章综述了癌症治疗中的纳米海绵,特别是基于环糊精的纳米海绵。(本实验)通过引用相关方向的不同尝试,来验证基于环糊精纳米海绵的特征,适应性和通用性,确定其在癌症治疗中的应用前景。
关键词: 生物利用度,癌症,环糊精,细胞毒性,纳米海绵,靶向输送
Current Drug Targets
Title:Nanosponge Carriers- An Archetype Swing in Cancer Therapy: A Comprehensive Review
Volume: 18 Issue: 1
Author(s): Riyaz Ali M. Osmani, Umme Hani, Rohit R. Bhosale, Parthasarathi K. Kulkarni, Seetharaman Shanmuganathan
Affiliation:
关键词: 生物利用度,癌症,环糊精,细胞毒性,纳米海绵,靶向输送
摘要: Nanotechnology and nanomedicines are emerging research meadows; which chiefly focuses on creating and manipulating materials at a nanometer level for the betterment in imaging, diagnosis and treatment of a range of diseases together with cancer. Cyclodextrin-based nanosponges, anticipated as a new-fangled nanosized delivery system, are ground-breaking hyper-crosslinked cyclodextrin polymers nanostructured within a three-dimensional network. Nanosponges based systems hold the potential of elevating the solubility, absorption, penetration, bioavailability, in vivo stability, targeted as well as sustained delivery, and therapeutic efficiency of numerous anticancer agents. The extension of nanosponges based drug delivery systems is an exhilarating and demanding research pasture, predominantly to overcome aforementioned problems allied to existing anticancer formulations and for the further progressions in cancer therapies. Nanosponges in cancer therapy, particularly cyclodextrin based nanosponges are brought up in this review. By quoting diverse attempts made in pertinent direction, efforts have been made to exemplify the characteristics, suitability and versatility of cyclodextrin based nanosponges for their promising applications in cancer treatment.
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Riyaz Ali M. Osmani, Umme Hani, Rohit R. Bhosale, Parthasarathi K. Kulkarni, Seetharaman Shanmuganathan , Nanosponge Carriers- An Archetype Swing in Cancer Therapy: A Comprehensive Review, Current Drug Targets 2017; 18 (1) . https://dx.doi.org/10.2174/1389450116666151001105449
DOI https://dx.doi.org/10.2174/1389450116666151001105449 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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